en Clinical Neuroscience Clinical Neuroscience Review Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:115%"><span lang="EN"><span style="line-height:115%">Phantom limb pain (PLP) and symptomatic neuromas remain major barriers to recovery after limb amputation, often limiting prosthetic use, mobility, and quality of life. Regenerative Peripheral Nerve Interfaces (RPNIs) have emerged as a promising biologically grounded technique for both neuroma prevention and targeted treatment of neuropathic post-amputation pain. This review synthesizes current evidence on RPNIs with specific attention to their surgical design, neurophysiological basis, and clinical effectiveness in reducing PLP and residual limb pain. In addition, the review examines mechanisms of axonal regeneration, the role of denervated muscle grafts in providing physiologic end-targets, and the potential of RPNIs to restore stable, high-fidelity motor signals for myoelectric prosthetic control. Comparative insights with Targeted Muscle Reinnervation (TMR) are included where appropriate. The aim is to provide a consolidated understanding of how RPNIs function at biological, electrophysiological, and clinical levels, and to identify current limitations and future directions in post-amputation nerve reconstruction.</span></span></span></span></span></div> Regenerative Peripheral Nerve Interface, Phantom Limb Pain, Phantom Limb Syndrome, Neuropathic Pain, Bionic Prosthesis, Myoelectric Control 51 61 http://neuroupdates.de/browse.php?a_code=A-10-1-58&slc_lang=en&sid=1 Arjun Jay Prakash arjunatschool@gmail.com 1003194753284600406 0009-0002-2063-0192 Yes Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia Mariam Kukchishvili mariam.quqchishvili@gmail.com 1003194753284600407 0009-0001-6477-0165 No Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia Ketevani Alavidze ketevanialavidze@gmail.com 1003194753284600408 0009-0009-2978-3620 No David Tvildiani Medical University, Tbilisi, Georgia Moustapha Abdelgadir Mohamed Khider mustafa.khider11@gmail.com 1003194753284600409 0009-0008-6112-6367 No Tbilisi State Medical University, Tbilisi, Georgia Quirina Cho Afanwi qafanwi@newvision.ge 1003194753284600410 0009-0002-7871-8218 No New Vision University, Tbilisi, Georgia Mohammed Muneer Yousuf Elnour 1003194753284600411 1003194753284600411 No Hamad General Hospital, Doha, Qatar