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Neuroscience Updates 2025, 3(1): 6-20 |
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Abbasi A A, Khan H, Jokhio F, Nisar N, Shoukat G, Hussain A. Role of Gut Microbiota on Neurological Disease During Early life. Neuroscience Updates 2025; 3 (1) :6-20
URL: http://neuroupdates.de/article-1-123-en.html
URL: http://neuroupdates.de/article-1-123-en.html
Adeel Ahmed Abbasi *1 
, Hamid Khan1 , Farhat Jokhio2 , Nusrat Nisar3 , Ghazala Shoukat4 , Abrar Hussain5
, Hamid Khan1 , Farhat Jokhio2 , Nusrat Nisar3 , Ghazala Shoukat4 , Abrar Hussain5
1- Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
2- Department of Psychology, University of Sindh, Jamshoro, Sindh, Pakistan
3- Liaqat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan
4- University of Sindh, Jamshoro, Sindh, Pakistan
5- Department of Neurosurgery, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
2- Department of Psychology, University of Sindh, Jamshoro, Sindh, Pakistan
3- Liaqat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan
4- University of Sindh, Jamshoro, Sindh, Pakistan
5- Department of Neurosurgery, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Abstract: (30 Views)
A person's microbiota is crucial to their health; this is particularly true for babies. The programming of infant health in the early years of life is influenced by the microbiota and its correlation to health in later years. The gut microbiota represents the most complex ecosystem of the human body and contains trillions of microorganisms. We consider the relationship of neurodevelopmental disease with the development of dysbiosis as a result of maternal dietary interventions and the potential implication for early brain development. A summary of the impact of maternal diet on neurodevelopmental disorders and the infant gut microbiome is presented here. Nevertheless, the potential mechanism involving the developmental and pathological effect of gut microbiota on the neurodevelopment also needs to be elucidated. In this sense, this review updates the role of the gut microbiota in early-life neurogenesis and neurological diseases. The gut microbiome, it is increasingly clear, is also a critical driver of brain health and mental well-being. We highlight specific gut microbiome-function-mediated pathways and mechanisms that influence the aetiology of cognitive conditions, including depression, anxiety, and autism-like conditions. In conclusion, the depiction of the gut microbiome as just an observer of the stress response, depression, anxiety and autism is developing as a thing of the past, and the essentiality of the gut microbiome as a key moderator has emerged. "Further work is needed to confirm whether the influence is direct or indirect and to optimise how beneficial microbes can be targeted." Such future research could include finding out how gut bacteria influence the function of the brain and the mind maybe even identifying which drugs could boost mental health by acting on the microbes.
Type of Study: Review Article |
Subject:
Neurodegenerative Disease
Received: 2025/02/9 | Accepted: 2025/04/14 | Published: 2025/04/23
Received: 2025/02/9 | Accepted: 2025/04/14 | Published: 2025/04/23
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