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Abbasi A A, Khan H, Jokhio F, Nisar N, Shoukat G, Hussain A. Role of Gut Microbiota on Neurological Disease During Early life. Neuroscience Updates 2025; 3 (1) :6-20
URL: http://neuroupdates.de/article-1-123-en.html
Role of Gut Microbiota on Neurological Disease During Early life
Adeel Ahmed Abbasi *1 , Hamid Khan1 , Farhat Jokhio2 , Nusrat Nisar3 , Ghazala Shoukat4 , Abrar Hussain5
1- Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
2- Department of Psychology, University of Sindh, Jamshoro, Sindh, Pakistan
3- Liaqat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan
4- University of Sindh, Jamshoro, Sindh, Pakistan
5- Department of Neurosurgery, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Abstract:   (94 Views)

A person's microbiota is crucial to their health; this is particularly true for babies. The programming of infant health in the early years of life is influenced by the microbiota and its correlation to health in later years. The gut microbiota represents the most complex ecosystem of the human body and contains trillions of microorganisms. We consider the relationship of neurodevelopmental disease with the development of dysbiosis as a result of maternal dietary interventions and the potential implication for early brain development. A summary of the impact of maternal diet on neurodevelopmental disorders and the infant gut microbiome is presented here. Nevertheless, the potential mechanism involving the developmental and pathological effect of gut microbiota on the neurodevelopment also needs to be elucidated.  In this sense, this review updates the role of the gut microbiota in early-life neurogenesis and neurological diseases. The gut microbiome, it is increasingly clear, is also a critical driver of brain health and mental well-being. We highlight specific gut microbiome-function-mediated pathways and mechanisms that influence the aetiology of cognitive conditions, including depression, anxiety, and autism-like conditions. In conclusion, the depiction of the gut microbiome as just an observer of the stress response, depression, anxiety and autism is developing as a thing of the past, and the essentiality of the gut microbiome as a key moderator has emerged. "Further work is needed to confirm whether the influence is direct or indirect and to optimise how beneficial microbes can be targeted." Such future research could include finding out how gut bacteria influence the function of the brain and the mind maybe even identifying which drugs could boost mental health by acting on the microbes.

Keywords: Neurogenesis, Neurological disease, Maternal diet, Anxiety, Depression, Autism
     
Type of Study: Review Article | Subject: Neurodegenerative Disease
Received: 2025/02/9 | Accepted: 2025/04/14 | Published: 2025/04/23
References
1. Mueller, N.T., et al., The infant microbiome development: mom matters. Trends Mol Med, 2015. 21(2): p. 109-17. [DOI:10.1016/j.molmed.2014.12.002] [PMID] [PMCID]
2. Human Microbiome Project, C., Structure, function and diversity of the healthy human microbiome. Nature, 2012. 486(7402): p. 207-14. [DOI:10.1038/nature11234] [PMID] [PMCID]
3. Lloyd-Price, J., G. Abu-Ali, and C. Huttenhower, The healthy human microbiome. Genome Med, 2016. 8(1): p. 51. [DOI:10.1186/s13073-016-0307-y] [PMID] [PMCID]
4. Sommer, F. and F. Backhed, The gut microbiota--masters of host development and physiology. Nat Rev Microbiol, 2013. 11(4): p. 227-38. [DOI:10.1038/nrmicro2974] [PMID]
5. Backhed, F., et al., Host-bacterial mutualism in the human intestine. Science, 2005. 307(5717): p. 1915-20. [DOI:10.1126/science.1104816] [PMID]
6. Uchimura, Y., et al., Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response. Immunity, 2018. 49(3): p. 545-559 e5. [DOI:10.1016/j.immuni.2018.08.004] [PMID] [PMCID]
7. Clarke, G., et al., The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry, 2013. 18(6): p. 666-73. [DOI:10.1038/mp.2012.77] [PMID] [PMCID]
8. Duvallet, C., et al., Meta-analysis of gut microbiome studies identifies disease-specific and shared responses. Nat Commun, 2017. 8(1): p. 1784. [DOI:10.1038/s41467-017-01973-8] [PMID] [PMCID]
9. Gil-Cruz, C., et al., Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. Science, 2019. 366(6467): p. 881-886. [DOI:10.1126/science.aav3487] [PMID]
10. Sudo, N., et al., Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol, 2004. 558(Pt 1): p. 263-75. [DOI:10.1113/jphysiol.2004.063388] [PMID] [PMCID]
11. Olson, C.A., et al., The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet. Cell, 2018. 174(2): p. 497. [DOI:10.1016/j.cell.2018.06.051] [PMID] [PMCID]
12. Valles-Colomer, M., et al., The neuroactive potential of the human gut microbiota in quality of life and depression. Nat Microbiol, 2019. 4(4): p. 623-632. [DOI:10.1038/s41564-018-0337-x] [PMID]
13. Inserra, A., et al., The Microbiota-Inflammasome Hypothesis of Major Depression. Bioessays, 2018. 40(9): p. e1800027. [DOI:10.1002/bies.201800027] [PMID] [PMCID]
14. Chu, C., et al., The microbiota regulate neuronal function and fear extinction learning. Nature, 2019. 574(7779): p. 543-548. [DOI:10.1038/s41586-019-1644-y] [PMID] [PMCID]
15. Iannone, L.F., et al., Microbiota-gut brain axis involvement in neuropsychiatric disorders. Expert Rev Neurother, 2019. 19(10): p. 1037-1050. [DOI:10.1080/14737175.2019.1638763] [PMID]
16. Blacher, E., et al., Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature, 2019. 572(7770): p. 474-480. [DOI:10.1038/s41586-019-1443-5] [PMID]
17. Oka, A., et al., Role of salivary microbiome in IL-10 production and efficacy of sublingual immunotherapy. Allergy, 2021. 76(8): p. 2617-2620. [DOI:10.1111/all.14858] [PMID]
18. Inoue, H., et al., Complete Genome Sequence of Bifidobacterium longum Strain Jih1, Isolated from Human Feces. Microbiol Resour Announc, 2020. 9(22). [DOI:10.1128/MRA.00319-20] [PMID] [PMCID]
19. Kalliomaki, M., et al., Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr, 2008. 87(3): p. 534-8. [DOI:10.1093/ajcn/87.3.534] [PMID]
20. Koenig, J.E., et al., Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A, 2011. 108 Suppl 1(Suppl 1): p. 4578-85. [DOI:10.1073/pnas.1000081107] [PMID] [PMCID]
21. Diaz Heijtz, R., Fetal, neonatal, and infant microbiome: Perturbations and subsequent effects on brain development and behavior. Semin Fetal Neonatal Med, 2016. 21(6): p. 410-417. [DOI:10.1016/j.siny.2016.04.012] [PMID]
22. McGlothen-Bell, K., et al., A Scoping Review of Neonatal Opioid Withdrawal and the Infant Gut Microbiome: Does Human Milk Optimize Infant Outcomes? Adv Neonatal Care, 2023. [DOI:10.1097/ANC.0000000000001056] [PMID]
23. Liu, X., et al., High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis. Cell Metab, 2021. 33(5): p. 923-938 e6. [DOI:10.1016/j.cmet.2021.02.002] [PMID]
24. Lee, S.K., Don't Worry, Heavy Moms; Just Eat Your Broccoli(or Kimchi)! Co-diet of high-fiber and high-fat helps give birth to healthy offspring through gut microbiota-to-brain signaling. Mol Cells, 2021. 44(6): p. 422-424. [DOI:10.14348/molcells.2021.0118] [PMID] [PMCID]
25. Sanders, A., H. Rackers, and M. Kimmel, A role for the microbiome in mother-infant interaction and perinatal depression. Int Rev Psychiatry, 2019. 31(3): p. 280-294. [DOI:10.1080/09540261.2018.1548431] [PMID]
26. Howell, K.R. and T.L. Powell, Effects of maternal obesity on placental function and fetal development. Reproduction, 2017. 153(3): p. R97-R108. [DOI:10.1530/REP-16-0495] [PMID] [PMCID]
27. Rivera, H.M., K.J. Christiansen, and E.L. Sullivan, The role of maternal obesity in the risk of neuropsychiatric disorders. Front Neurosci, 2015. 9: p. 194. [DOI:10.3389/fnins.2015.00194] [PMCID]
28. Bruce-Keller, A.J., et al., Maternal obese-type gut microbiota differentially impact cognition, anxiety and compulsive behavior in male and female offspring in mice. PLoS One, 2017. 12(4): p. e0175577. [DOI:10.1371/journal.pone.0175577] [PMID] [PMCID]
29. Muhle, R.A., et al., The Emerging Clinical Neuroscience of Autism Spectrum Disorder: A Review. JAMA Psychiatry, 2018. 75(5): p. 514-523. [DOI:10.1001/jamapsychiatry.2017.4685] [PMID]
30. de la Torre-Ubieta, L., et al., Advancing the understanding of autism disease mechanisms through genetics. Nat Med, 2016. 22(4): p. 345-61. [DOI:10.1038/nm.4071] [PMID] [PMCID]
31. Di Gesu, C.M., L.M. Matz, and S.A. Buffington, Diet-induced dysbiosis of the maternal gut microbiome in early life programming of neurodevelopmental disorders. Neurosci Res, 2021. 168: p. 3-19. [DOI:10.1016/j.neures.2021.05.003] [PMID] [PMCID]
32. Zhao, C., W. Deng, and F.H. Gage, Mechanisms and functional implications of adult neurogenesis. Cell, 2008. 132(4): p. 645-60. [DOI:10.1016/j.cell.2008.01.033] [PMID]
33. Gage, F.H., Mammalian neural stem cells. Science, 2000. 287(5457): p. 1433-8. [DOI:10.1126/science.287.5457.1433] [PMID]
34. Riquelme, P.A., E. Drapeau, and F. Doetsch, Brain micro-ecologies: neural stem cell niches in the adult mammalian brain. Philos Trans R Soc Lond B Biol Sci, 2008. 363(1489): p. 123-37. [DOI:10.1098/rstb.2006.2016] [PMID] [PMCID]
35. Alvarez-Buylla, A. and D.A. Lim, For the long run: maintaining germinal niches in the adult brain. Neuron, 2004. 41(5): p. 683-6. [DOI:10.1016/S0896-6273(04)00111-4] [PMID]
36. Lu, J. and E.C. Claud, Connection between gut microbiome and brain development in preterm infants. Dev Psychobiol, 2019. 61(5): p. 739-751. [DOI:10.1002/dev.21806] [PMID] [PMCID]
37. Calatayud Arroyo, M., et al., A review of the impact of xenobiotics from dietary sources on infant health: Early life exposures and the role of the microbiota. Environ Pollut, 2021. 269: p. 115994. [DOI:10.1016/j.envpol.2020.115994] [PMID]
38. Avershina, E., et al., Transition from infant- to adult-like gut microbiota. Environ Microbiol, 2016. 18(7): p. 2226-36. [DOI:10.1111/1462-2920.13248] [PMID]
39. Milani, C., et al., Exploring Vertical Transmission of Bifidobacteria from Mother to Child. Appl Environ Microbiol, 2015. 81(20): p. 7078-87. [DOI:10.1128/AEM.02037-15] [PMID] [PMCID]
40. Underwood, M.A., et al., Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatr Res, 2015. 77(1-2): p. 229-35. [DOI:10.1038/pr.2014.156] [PMID] [PMCID]
41. Alcon-Giner, C., et al., Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study. Cell Rep Med, 2020. 1(5): p. 100077. [DOI:10.1016/j.xcrm.2020.100077] [PMID] [PMCID]
42. Yao, Y., et al., The Role of Microbiota in Infant Health: From Early Life to Adulthood. Front Immunol, 2021. 12: p. 708472. [DOI:10.3389/fimmu.2021.708472] [PMID] [PMCID]
43. Solis, G., et al., Establishment and development of lactic acid bacteria and bifidobacteria microbiota in breast-milk and the infant gut. Anaerobe, 2010. 16(3): p. 307-10. [DOI:10.1016/j.anaerobe.2010.02.004] [PMID]
44. Kiu, R., et al., Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights. Genome Biol Evol, 2017. 9(10): p. 2707-2714. [DOI:10.1093/gbe/evx210] [PMID] [PMCID]
45. Cui, Q.Q., et al., Epidemiological investigation of Clostridioides difficile colonization in Chinese community infants. Anaerobe, 2019. 56: p. 116-123. [DOI:10.1016/j.anaerobe.2019.01.008] [PMID]
46. Feng, D., et al., Modeling of Symbiotic Bacterial Biofilm Growth with an Example of the Streptococcus-Veillonella sp. System. Bull Math Biol, 2021. 83(5): p. 48. [DOI:10.1007/s11538-021-00888-2] [PMID] [PMCID]
47. Gregory, K.E., et al., Mode of Birth Influences Preterm Infant Intestinal Colonization With Bacteroides Over the Early Neonatal Period. Adv Neonatal Care, 2015. 15(6): p. 386-93. [DOI:10.1097/ANC.0000000000000237] [PMID] [PMCID]
48. Dogra, S., et al., Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity. mBio, 2015. 6(1). [DOI:10.1128/mBio.02419-14] [PMID] [PMCID]
49. Cassidy-Bushrow, A.E., et al., Maternal group B Streptococcus and the infant gut microbiota. J Dev Orig Health Dis, 2016. 7(1): p. 45-53. [DOI:10.1017/S2040174415001361] [PMID] [PMCID]
50. Kageyama, A., Y. Benno, and T. Nakase, Phylogenetic and phenotypic evidence for the transfer of Eubacterium aerofaciens to the genus Collinsella as Collinsella aerofaciens gen. nov., comb. nov. Int J Syst Bacteriol, 1999. 49 Pt 2: p. 557-65. [DOI:10.1099/00207713-49-2-557] [PMID]
51. Durand, G.A., et al., Description of 'Gorbachella massiliensis' gen. nov., sp. nov., 'Fenollaria timonensis' sp. nov., 'Intestinimonas timonensis' sp. nov. and 'Collinsella ihuae' sp. nov. isolated from healthy fresh stools with culturomics. New Microbes New Infect, 2017. 16: p. 60-62. [DOI:10.1016/j.nmni.2017.01.005] [PMID] [PMCID]
52. Derrien, M., et al., The Mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract. Appl Environ Microbiol, 2008. 74(5): p. 1646-8. [DOI:10.1128/AEM.01226-07] [PMID] [PMCID]
53. Derrien, M., et al., Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int J Syst Evol Microbiol, 2004. 54(Pt 5): p. 1469-1476. [DOI:10.1099/ijs.0.02873-0] [PMID]
54. Collado, M.C., et al., Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly. Appl Environ Microbiol, 2007. 73(23): p. 7767-70. [DOI:10.1128/AEM.01477-07] [PMID] [PMCID]
55. Everard, A., et al., Crosstalk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A, 2013. 110(22): p. 9066-71. [DOI:10.1073/pnas.1219451110] [PMID] [PMCID]
56. Battle, D.E., Diagnostic and Statistical Manual of Mental Disorders (DSM). Codas, 2013. 25(2): p. 191-2.
57. Jansson, T. and T.L. Powell, Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci (Lond), 2007. 113(1): p. 1-13. [DOI:10.1042/CS20060339] [PMID]
58. Bourgeron, T., From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat Rev Neurosci, 2015. 16(9): p. 551-63. [DOI:10.1038/nrn3992] [PMID] [PMCID]
59. Parenti, I., et al., Neurodevelopmental Disorders: From Genetics to Functional Pathways. Trends Neurosci, 2020. 43(8): p. 608-621. [DOI:10.1016/j.tins.2020.05.004] [PMID]
60. De Felice, A., et al., Multifactorial Origin of Neurodevelopmental Disorders: Approaches to Understanding Complex Etiologies. Toxics, 2015. 3(1): p. 89-129. [DOI:10.3390/toxics3010089] [PMID] [PMCID]
61. Dinan, T.G., et al., Collective unconscious: how gut microbes shape human behavior. J Psychiatr Res, 2015. 63: p. 1-9. [DOI:10.1016/j.jpsychires.2015.02.021] [PMID]
62. Gonzalez, A., et al., The mind-body-microbial continuum. Dialogues Clin Neurosci, 2011. 13(1): p. 55-62. [DOI:10.31887/DCNS.2011.13.1/agonzalez] [PMID] [PMCID]
63. Adlerberth, I. and A.E. Wold, Establishment of the gut microbiota in Western infants. Acta Paediatr, 2009. 98(2): p. 229-38. [DOI:10.1111/j.1651-2227.2008.01060.x] [PMID]
64. de Weerth, C., Do bacteria shape our development? Crosstalk between intestinal microbiota and HPA axis. Neurosci Biobehav Rev, 2017. 83: p. 458-471. [DOI:10.1016/j.neubiorev.2017.09.016] [PMID]
65. Tremaroli, V. and F. Backhed, Functional interactions between the gut microbiota and host metabolism. Nature, 2012. 489(7415): p. 242-9. [DOI:10.1038/nature11552] [PMID]
66. Nicholson, J.K., et al., Host-gut microbiota metabolic interactions. Science, 2012. 336(6086): p. 1262-7. [DOI:10.1126/science.1223813] [PMID]
67. Du, Y., et al., Crosstalk between the microbiota-gut-brain axis and depression. Heliyon, 2020. 6(6): p. e04097. [DOI:10.1016/j.heliyon.2020.e04097] [PMID] [PMCID]
68. Foster, J.A. and K.A. McVey Neufeld, Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci, 2013. 36(5): p. 305-12. [DOI:10.1016/j.tins.2013.01.005] [PMID] [PMCID]
69. Gill, S.R., et al., Metagenomic analysis of the human distal gut microbiome. Science, 2006. 312(5778): p. 1355-9. [DOI:10.1126/science.1124234] [PMID] [PMCID]
70. Neufeld, K.A., et al., Effects of intestinal microbiota on anxiety-like behavior. Commun Integr Biol, 2011. 4(4): p. 492-4. [DOI:10.4161/cib.15702] [PMID] [PMCID]
71. Jorm, A.F., et al., Has increased provision of treatment reduced the prevalence of common mental disorders? Review of the evidence from four countries. World Psychiatry, 2017. 16(1): p. 90-99. [DOI:10.1002/wps.20388] [PMID] [PMCID]
72. Friedrich, M.J., Depression Is the Leading Cause of Disability Around the World. JAMA, 2017. 317(15): p. 1517. [DOI:10.1001/jama.2017.3826]
73. Tognini, P., Gut Microbiota: A Potential Regulator of Neurodevelopment. Front Cell Neurosci, 2017. 11: p. 25. [DOI:10.3389/fncel.2017.00025] [PMID] [PMCID]
74. Bastiaanssen, T.F.S., et al., Making Sense of ... the Microbiome in Psychiatry. Int J Neuropsychopharmacol, 2019. 22(1): p. 37-52. [DOI:10.1093/ijnp/pyy067] [PMID] [PMCID]
75. Jiang, H.Y., et al., Altered gut microbiota profile in patients with generalized anxiety disorder. J Psychiatr Res, 2018. 104: p. 130-136. [DOI:10.1016/j.jpsychires.2018.07.007] [PMID]
76. Blekhman, R., et al., Host genetic variation impacts microbiome composition across human body sites. Genome Biol, 2015. 16(1): p. 191. [DOI:10.1186/s13059-015-0759-1] [PMID] [PMCID]
77. Schirmer, M., et al., Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity. Cell, 2016. 167(7): p. 1897. [DOI:10.1016/j.cell.2016.11.046] [PMID]
78. Carabotti, M., et al., The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol, 2015. 28(2): p. 203-209.
79. Rogers, G.B., et al., From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. Mol Psychiatry, 2016. 21(6): p. 738-48. [DOI:10.1038/mp.2016.50] [PMID] [PMCID]
80. Schrezenmeir, J. and M. de Vrese, Probiotics, prebiotics, and synbiotics--approaching a definition. Am J Clin Nutr, 2001. 73(2 Suppl): p. 361S-364S. [DOI:10.1093/ajcn/73.2.361s]
81. McDonald, S.D., et al., The combined effects of maternal depression and excess weight on neonatal outcomes. Int J Obes (Lond), 2015. 39(7): p. 1033-40. [DOI:10.1038/ijo.2015.44] [PMID]
82. Gawlinska, K., et al., Maternal high-fat diet during pregnancy and lactation provokes depressive-like behavior and influences the irisin/brain-derived neurotrophic factor axis and inflammatory factors in male and female offspring in rats. J Physiol Pharmacol, 2019. 70(3).
83. Hatanaka, Y., T. Kabuta, and K. Wada, Disturbance in Maternal Environment Leads to Abnormal Synaptic Instability during Neuronal Circuitry Development. Front Neurosci, 2017. 11: p. 35. [DOI:10.3389/fnins.2017.00035] [PMID] [PMCID]
84. Trujillo-Villarreal, L.A., et al., Maternal cafeteria diet exposure primes depression-like behavior in the offspring evoking lower brain volume related to changes in synaptic terminals and gliosis. Transl Psychiatry, 2021. 11(1): p. 53. [DOI:10.1038/s41398-020-01157-x] [PMID] [PMCID]
85. Winter, C., et al., Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats. Behav Brain Res, 2007. 184(2): p. 133-41. [DOI:10.1016/j.bbr.2007.07.002] [PMID]
86. Belujon, P. and A.A. Grace, Dopamine System Dysregulation in Major Depressive Disorders. Int J Neuropsychopharmacol, 2017. 20(12): p. 1036-1046. [DOI:10.1093/ijnp/pyx056] [PMID] [PMCID]
87. Thion, M.S., et al., Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner. Cell, 2018. 172(3): p. 500-516 e16. [DOI:10.1016/j.cell.2017.11.042] [PMID] [PMCID]
88. Buffington, S.A., et al., Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring. Cell, 2016. 165(7): p. 1762-1775. [DOI:10.1016/j.cell.2016.06.001] [PMID] [PMCID]
89. Duan, C., et al., Gut commensal-derived butyrate reverses obesity-induced social deficits and anxiety-like behaviors via regulation of microglial homeostasis. Eur J Pharmacol, 2021. 908: p. 174338. [DOI:10.1016/j.ejphar.2021.174338] [PMID]
90. Jantsch, J., et al., Mood Disorders Induced by Maternal Overnutrition: The Role of the Gut-Brain Axis on the Development of Depression and Anxiety. Front Cell Dev Biol, 2022. 10: p. 795384. [DOI:10.3389/fcell.2022.795384] [PMID] [PMCID]
91. Menting, M.D., et al., The link between maternal obesity and offspring neurobehavior: A systematic review of animal experiments. Neurosci Biobehav Rev, 2019. 98: p. 107-121. [DOI:10.1016/j.neubiorev.2018.12.023] [PMID]
92. Sasaki, A., et al., Maternal high-fat diet alters anxiety behavior and glucocorticoid signaling in adolescent offspring. Neuroscience, 2014. 272: p. 92-101. [DOI:10.1016/j.neuroscience.2014.04.012] [PMID]
93. Matuszewska, J., et al., Mothers' cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring. Sci Rep, 2021. 11(1): p. 18573. [DOI:10.1038/s41598-021-97487-x] [PMID] [PMCID]
94. Wright, T., S.C. Langley-Evans, and J.P. Voigt, The impact of maternal cafeteria diet on anxiety-related behaviour and exploration in the offspring. Physiol Behav, 2011. 103(2): p. 164-72. [DOI:10.1016/j.physbeh.2011.01.008] [PMID]
95. Ribeiro, A., et al., Cafeteria diet during the gestation period programs developmental and behavioral courses in the offspring. Int J Dev Neurosci, 2018. 68: p. 45-52. [DOI:10.1016/j.ijdevneu.2018.05.001] [PMID]
96. Constantino, J.N., et al., Timing of the diagnosis of autism in African American children. Pediatrics, 2020. 146(3). [DOI:10.1542/peds.2019-3629] [PMID] [PMCID]
97. Sandin, S., et al., The heritability of autism spectrum disorder. Jama, 2017. 318(12): p. 1182-1184. [DOI:10.1001/jama.2017.12141] [PMID] [PMCID]
98. Ho, L.K.H., et al., Gut microbiota changes in children with autism spectrum disorder: a systematic review. Gut Pathog, 2020. 12: p. 6. [DOI:10.1186/s13099-020-0346-1] [PMID] [PMCID]
99. Lefter, R., et al., A Descriptive Review on the Prevalence of Gastrointestinal Disturbances and Their Multiple Associations in Autism Spectrum Disorder. Medicina (Kaunas), 2019. 56(1). [DOI:10.3390/medicina56010011] [PMID] [PMCID]
100. Hsiao, E.Y., et al., Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell, 2013. 155(7): p. 1451-63. [DOI:10.1016/j.cell.2013.11.024] [PMID] [PMCID]
101. Zeisel, S.H., Epigenetic mechanisms for nutrition determinants of later health outcomes. Am J Clin Nutr, 2009. 89(5): p. 1488S-1493S. [DOI:10.3945/ajcn.2009.27113B] [PMID] [PMCID]
102. Niculescu, M.D. and D.S. Lupu, Nutritional influence on epigenetics and effects on longevity. Curr Opin Clin Nutr Metab Care, 2011. 14(1): p. 35-40. [DOI:10.1097/MCO.0b013e328340ff7c] [PMID]
103. Golonka, R.M., et al., Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis. Curr Hypertens Rep, 2021. 23(5): p. 28. [DOI:10.1007/s11906-021-01142-9] [PMID] [PMCID]
104. Saetrom, P., O. Snove, Jr., and J.J. Rossi, Epigenetics and microRNAs. Pediatr Res, 2007. 61(5 Pt 2): p. 17R-23R. [DOI:10.1203/pdr.0b013e318045760e] [PMID]
105. Lewis, B.P., et al., Prediction of mammalian microRNA targets. Cell, 2003. 115(7): p. 787-98. [DOI:10.1016/S0092-8674(03)01018-3] [PMID] [PMCID]
106. Lim, L.P., et al., Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature, 2005. 433(7027): p. 769-73. [DOI:10.1038/nature03315] [PMID]
107. Moutinho, C. and M. Esteller, MicroRNAs and Epigenetics. Adv Cancer Res, 2017. 135: p. 189-220. [DOI:10.1016/bs.acr.2017.06.003] [PMID]
108. Ponting, C.P., P.L. Oliver, and W. Reik, Evolution and functions of long noncoding RNAs. Cell, 2009. 136(4): p. 629-41. [DOI:10.1016/j.cell.2009.02.006] [PMID]
109. Garcia-Casal, M.N., D. Estevez, and L.M. De-Regil, Multiple micronutrient supplements in pregnancy: Implementation considerations for integration as part of quality services in routine antenatal care. Objectives, results, and conclusions of the meeting. Matern Child Nutr, 2018. 14 Suppl 5(Suppl 5): p. e12704. [DOI:10.1111/mcn.12704] [PMID] [PMCID]
110. Afroz, K.F. and K. Alvina, Maternal elevated salt consumption and the development of autism spectrum disorder in the offspring. J Neuroinflammation, 2019. 16(1): p. 265. [DOI:10.1186/s12974-019-1666-2] [PMID] [PMCID]
111. Morris, G., et al., The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease. Mol Neurobiol, 2017. 54(6): p. 4432-4451. [DOI:10.1007/s12035-016-0004-2] [PMID]
112. Monk, C., M.K. Georgieff, and E.A. Osterholm, Research review: maternal prenatal distress and poor nutrition - mutually influencing risk factors affecting infant neurocognitive development. J Child Psychol Psychiatry, 2013. 54(2): p. 115-30. [DOI:10.1111/jcpp.12000] [PMID] [PMCID]
113. Chen, C., X. Xu, and Y. Yan, Estimated global overweight and obesity burden in pregnant women based on panel data model. PLoS One, 2018. 13(8): p. e0202183. [DOI:10.1371/journal.pone.0202183] [PMID] [PMCID]
114. Bleich, S., et al., Why is the developed world obese? Annu Rev Public Health, 2008. 29: p. 273-95. [DOI:10.1146/annurev.publhealth.29.020907.090954] [PMID]
115. Montalvo-Martinez, L., et al., Maternal Overnutrition Programs Central Inflammation and Addiction-Like Behavior in Offspring. Biomed Res Int, 2018. 2018: p. 8061389. [DOI:10.1155/2018/8061389] [PMID] [PMCID]
116. Bilbo, S.D. and V. Tsang, Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J, 2010. 24(6): p. 2104-15. [DOI:10.1096/fj.09-144014] [PMID]
117. Buyken, A.E., et al., Association between carbohydrate quality and inflammatory markers: systematic review of observational and interventional studies. Am J Clin Nutr, 2014. 99(4): p. 813-33. [DOI:10.3945/ajcn.113.074252] [PMID]
118. Blumfield, M.L., et al., A systematic review and meta-analysis of micronutrient intakes during pregnancy in developed countries. Nutr Rev, 2013. 71(2): p. 118-32. [DOI:10.1111/nure.12003] [PMID]
119. Visentin, C.E., et al., Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women. J Nutr, 2016. 146(5): p. 1035-42. [DOI:10.3945/jn.115.226845] [PMID]
120. Graf, A.E., et al., Maternal high fat diet exposure is associated with increased hepcidin levels, decreased myelination, and neurobehavioral changes in male offspring. Brain Behav Immun, 2016. 58: p. 369-378. [DOI:10.1016/j.bbi.2016.08.005] [PMID] [PMCID]
121. Winther, G., et al., Maternal High-fat Diet Programs Offspring Emotional Behavior in Adulthood. Neuroscience, 2018. 388: p. 87-101. [DOI:10.1016/j.neuroscience.2018.07.014] [PMID]
122. Bordeleau, M., et al., Microglia along sex lines: From brain colonization, maturation and function, to implication in neurodevelopmental disorders. Semin Cell Dev Biol, 2019. 94: p. 152-163. [DOI:10.1016/j.semcdb.2019.06.001] [PMID]
123. Madore, C., et al., Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain. Nat Commun, 2020. 11(1): p. 6133. [DOI:10.1038/s41467-020-19861-z] [PMID] [PMCID]
124. Tay, T.L., et al., Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan. Front Mol Neurosci, 2017. 10: p. 421. [DOI:10.3389/fnmol.2017.00421] [PMID] [PMCID]
125. Schwarz, J.M. and S.D. Bilbo, Sex, glia, and development: interactions in health and disease. Horm Behav, 2012. 62(3): p. 243-53. [DOI:10.1016/j.yhbeh.2012.02.018] [PMID] [PMCID]
126. Mallya, A.P., et al., Microglial Pruning of Synapses in the Prefrontal Cortex During Adolescence. Cereb Cortex, 2019. 29(4): p. 1634-1643. [DOI:10.1093/cercor/bhy061] [PMID] [PMCID]
127. Bennett, M.L. and B.A. Barres, A genetically distinct microglial subset promotes myelination. EMBO J, 2017. 36(22): p. 3269-3271. [DOI:10.15252/embj.201798389] [PMID] [PMCID]
128. Hagemeyer, N., et al., Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood. Acta Neuropathol, 2017. 134(3): p. 441-458. [DOI:10.1007/s00401-017-1747-1] [PMID] [PMCID]
129. Lacoste, B. and C. Gu, Control of cerebrovascular patterning by neural activity during postnatal development. Mech Dev, 2015. 138 Pt 1: p. 43-9. [DOI:10.1016/j.mod.2015.06.003] [PMID] [PMCID]
130. Arnold, T. and C. Betsholtz, The importance of microglia in the development of the vasculature in the central nervous system. Vasc Cell, 2013. 5(1): p. 4. [DOI:10.1186/2045-824X-5-4] [PMID] [PMCID]
131. Matcovitch-Natan, O., et al., Microglia development follows a stepwise program to regulate brain homeostasis. Science, 2016. 353(6301): p. aad8670. [DOI:10.1126/science.aad8670] [PMID]
132. Castillo-Ruiz, A., et al., The microbiota influences cell death and microglial colonization in the perinatal mouse brain. Brain Behav Immun, 2018. 67: p. 218-229. [DOI:10.1016/j.bbi.2017.08.027] [PMID] [PMCID]
133. Effah, F., et al., Region-specific sex modulation of central oxytocin receptor by gut microbiota: An ontogenic study. Dev Neurobiol, 2021. 81(2): p. 149-163. [DOI:10.1002/dneu.22805] [PMID]
134. Vaidyanathan, R. and E.A. Hammock, Oxytocin receptor dynamics in the brain across development and species. Dev Neurobiol, 2017. 77(2): p. 143-157. [DOI:10.1002/dneu.22403] [PMID]
135. Dumais, K.M. and A.H. Veenema, Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior. Front Neuroendocrinol, 2016. 40: p. 1-23. [DOI:10.1016/j.yfrne.2015.04.003] [PMID] [PMCID]
136. Grinevich, V., et al., Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders. Front Neuroanat, 2014. 8: p. 164. [DOI:10.3389/fnana.2014.00164] [PMID] [PMCID]
137. Cirulli, F., C. Musillo, and A. Berry, Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring. Neuroscience, 2020. 447: p. 122-135. [DOI:10.1016/j.neuroscience.2020.01.023] [PMID]
138. Cryan, J.F. and S.M. O'Mahony, The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterol Motil, 2011. 23(3): p. 187-92. [DOI:10.1111/j.1365-2982.2010.01664.x] [PMID]
139. Dinan, T.G. and J.F. Cryan, Mood by microbe: towards clinical translation. Genome Med, 2016. 8(1): p. 36. [DOI:10.1186/s13073-016-0292-1] [PMID] [PMCID]
140. Warner, B.B., The contribution of the gut microbiome to neurodevelopment and neuropsychiatric disorders. Pediatr Res, 2019. 85(2): p. 216-224. [DOI:10.1038/s41390-018-0191-9] [PMID]
141. Sgritta, M., et al., Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. Neuron, 2019. 101(2): p. 246-259 e6. [DOI:10.1016/j.neuron.2018.11.018] [PMID] [PMCID]
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