Volume 3, Issue 1 (1-2025)  

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XML Brain Health and Aging: How Nutrition Can Keep the Health
P. 1-5
Nasrollah Moradikor *
Abstract (2702 Views)   |   Graphical Abstract   |   Reseach Highlights
Graphical Abstract:

Reseach Highlights:
  • Aging is a major risk factor for neurodegenerative diseases.
  • Healthy aging relies on nutrient-rich dietary patterns and smart eating habits.
  • Functional foods are a promising approach to preventing age-related diseases.
  • Vitamin D, omega-3 fatty acids, and B vitamins are among the essential nutrients for brain function.


XML Role of Gut Microbiota on Neurological Disease During Early life
P. 6-20
Adeel Ahmed Abbasi * , Hamid Khan , Farhat Jokhio , Nusrat Nisar , Ghazala Shoukat , Abrar Hussain
Abstract (2759 Views)   |   Graphical Abstract   |   Reseach Highlights
Graphical Abstract:

Reseach Highlights:
  • Maternal diet shapes infant gut microbiota and early brain development.
  • Gut dysbiosis links to autism, anxiety, and depression risk.
  • Trillions of microbes influence neurogenesis during critical early-life windows.
  • Microbiome acts as key moderator, not mere observer, of stress.
  • Targeting beneficial microbes may offer novel mental health therapies.


XML Microsurgical Clipping versus Endovascular Coiling in Ruptured and Unruptured Anterior Circulation Aneurysms: A Literature Review
P. 21-35
Marwan Jaber * , Hassan Khalid , Sarah Ansari , Ali Banafa , Haneen Elagib , Erekle Ekvtimishvili
Abstract (2820 Views)   |   Graphical Abstract   |   Reseach Highlights
Graphical Abstract:

Reseach Highlights:
  •  
  • Microsurgical clipping (MC) consistently demonstrated superior angiographic occlusion rates compared to endovascular coiling (EC).
  • Aneurysms treated with endovascular coiling showed higher rate of recurrence, thereby higher rates of retreatment.
  • MC demonstrated a vital survival advantage compared with EC in ruptured aneurysms across different locations.
  • Endovascular coiling showed better results in terms of intracranial infection and delayed cerebral ischemia.
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XML Redefining Anticoagulation in Neurosurgical Patients with Atrial Fibrillation: A Narrative Review of Risk Mitigation and Personalized Neuroprotection
P. 36-50
Parvin Mozafari * , Garin Basmajian , Daniya Rahmath , Alvina Kalsahakian , Mohammed Hamza Sayed , Mohammad Hassan Bagheri
Abstract (2804 Views)   |   Graphical Abstract   |   Reseach Highlights
Graphical Abstract:

Reseach Highlights:
  • Develop individualized plans for anticoagulation in patients with AF who require neurosurgery to enhance outcomes.
  • Establish a neuro-safe window to guide the resumption of postoperative anticoagulation with a minimum of hemorrhagic complications.
  • Identify issues with traditional systemic risk scores used in neurosurgical anticoagulation.
  • Review neuro-specific monitoring systems, to optimize individualized perioperative management of antithrombotic therapy.
  • Educate about the neuroprotective benefits of DOACs and specific reversal strategies.


XML Regenerative Peripheral Nerve Interfaces for management of Phantom limb pain in amputees
P. 51-61
Arjun Jay Prakash * , Mariam Kukchishvili , Ketevani Alavidze , Moustapha Abdelgadir Mohamed Khider , Quirina Cho Afanwi , Mohammed Muneer Yousuf Elnour
Abstract (2769 Views)   |   Graphical Abstract   |   Reseach Highlights
Graphical Abstract:

Reseach Highlights:
 
  • Regenerative peripheral nerve interfaces provide a physiologic muscle end-target, effectively preventing disorganized axonal growth and neuroma formation.
  • ​Clinical applications demonstrate significant reductions in post-amputation pain scores alongside decreased long-term opioid dependence.
  • ​Prophylactic integration of muscle interfaces during primary amputation ensures superior long-term pain mitigation and functional recovery.
  • ​The reinnervated muscle graft functions as a stable biological signal amplifier for high-fidelity myoelectric prosthetic control.
 


XML Beyond Thrombectomy: A Comprehensive Narrative Review of Rescue Angioplasty and Stenting in Refractory Large-Vessel Occlusion Stroke
P. 62-75
Parvin Mozafari , Tatia Tsiklauri , Salome Lobzhanidze , Giorgi Bakuridze , Ana Anakidze * , Mohammad Hassan Bagheri
Abstract (2869 Views)   |   Graphical Abstract   |   Reseach Highlights
Graphical Abstract:

Reseach Highlights:
  • Make it clear that intracranial atherosclerotic disease is the main reason of mechanical thrombectomy failure.
  • Show that rescue angioplasty and stenting is highly effective in recanalizing refractory large vessel occlusion.
  • Explain better functional outcomes at 90 days after rescue endovascular intervention for failed thrombectomy.
  • Recognize that the primary safety risk of "rescue therapies" is ICP.
  • Emphasize the need for uniform criteria for patient selection and peri-procedural treatment.


XML Autoimmune Encephalitis Mimicking Primary Psychiatric Disorders: A Narrative Review
P. 76-100
George P. Roy * , Abdullah Faez Banafea , Aryan Sanjiv Kadam , Baminahennadige Nuran Monuja Peiris , Rathnayake Mudiyanselage AkshinNehara Rathnaweera , Tamar Akhvlediani
Abstract (2766 Views)   |   Graphical Abstract   |   Reseach Highlights
Graphical Abstract:

Reseach Highlights:
  • Autoimmune encephalitis frequently presents with psychiatric symptoms, obscuring diagnostic boundaries between neurology and psychiatry.
  • Early immunotherapy improves outcomes, showing the importance of recognizing rapid symptom progression and treatment resistance.
  • Epidemiological studies reveal psychiatric manifestations in nearly half of encephalitis patients, increasing misdiagnosis and hospitalization.
  • Comprehensive evaluation establishes diagnosis through cerebrospinal fluid antibody testing, neuroimaging, and excluding primary psychiatric disorders.
  • Long-term management addresses persistent cognitive and mood impairments through multidisciplinary rehabilitation and structured follow-up care.


XML LRP1 and Microglial Dysfunction in Alzheimer’s Disease: Mechanistic Crosstalk, Dual-Target Therapeutic Strategies, and Sleep-Oriented Adjunctive Approaches
P. 101-115
Adeel Ahmed Abbasi , Ali Fereidouni , Nasrollah Moradikor *
Abstract (2970 Views)   |   Graphical Abstract   |   Reseach Highlights
Graphical Abstract:

Reseach Highlights:
  • LRP1 downregulation impairs amyloid-beta clearance, accelerating Alzheimer's disease progression.
  • Microglial senescence drives inflammation, phagocytic loss, and lysosomal dysfunction.
  • Dual-target therapy combines engineered microglia with LRP1 and CMA enhancement.
  • Glymphatic dysfunction and sleep disturbances worsen microglial dysregulation in Alzheimer's.
  • Sleep-supportive supplements offer adjunct therapy to boost cognitive resilience.


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