en Neurodegenerative Disease Neurodegenerative Disease Review Article <div style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Tahoma;"><span style="font-size:14px;">This review shows challenges neurological pathologies of various disorders inducing migraine, amyotrophic lateral sclerosis, Parkinson&#39;s, Alzheimer&#39;s, and Huntington&#39;s diseases caused by stress. Long-lasting stress triggers a series of biochemical reactions that cause the degeneration of neurons and causing long-lasting cognitive impairment. The most cause of neurological disorders are oxidative stress, neuroinflammation, and mitochondrial dysfunction. In the case of Alzheimer&#39;s disease, stress can exacerbate Alzheimer&#39;s pathology by enhancing&nbsp;tau protein to be phosphorylated and triggering the misfolding of amyloid-beta protein. Stress in Parkinson&rsquo;s disease is a leading factor in alpha-synuclein aggregation and the subsequent death of dopaminergic neurons. A variety of therapeutic strategies aimed at mitigating these stress-related pathways are under investigation as anti-inflammatory strategies, antioxidant therapies, and agents supporting mitochondrial function. The review outlines neuroprotective effects of lifestyle interventions: cognitive behavioral therapy, regular physical exercise, and diet-related approaches. current research underlines the need for comprehensive therapeutic approaches targeting stress-related mechanisms in attempts to delay the causes of neurodegenerative diseases and improve patient health.</span></span></span></div> Oxidative stress, Chronic stress, Brain inflammation, Mitochondrial dysfunction, Neurodegenerative disorders 67 98 http://neuroupdates.de/browse.php?a_code=A-10-1-50&slc_lang=en&sid=1 Radwa Abdallnasser Amen 1003194753284600304 1003194753284600304 No Department of Biotechnology, Faculty of Science, Cairo University, Egypt Rawan Atef Essmat 1003194753284600305 0009-0001-1645-9700 No Faculty of Pharmacy, Modern University for Information and Technology, Egypt Esraa Mohamed Atallah eatallah57@gmail.com 1003194753284600306 0009-0004-2283-8776 Yes Department of Zoology, Faculty of Science, Mansoura University, Egypt