en Neurodegenerative Disease Neurodegenerative Disease Review Article <div style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Tahoma;"><span style="font-size:14px;">This review explores the emerging insights into the gut-brain axis (GBA) and its dysregulation in neurodegenerative disorders such as Alzheimer&#39;s, Parkinson&#39;s, and Huntington&#39;s. The GBA represents a complex communication network linking the intestinal microbiome with the central nervous system (CNS), facilitated by neuro-immuno-endocrine mediators. Such interactions profoundly influence brain health, cognitive functions, and various systemic diseases. Dysbiosis of gut microbiota may be implicated in the pathogenesis of neurodegenerative conditions through mechanisms involving inflammation, metabolic regulation, and neurotransmitter activity. Additionally, dietary habits, lifestyle choices, and environmental factors significantly affect individual gut microbiota profiles, further shaping neurological health. The review highlights the potential of microbiome-based therapies as innovative intervention strategies, emphasizing the metabolic contribution of gut bacteria, such as short-chain fatty acids (SCFAs), to brain function and mood regulation. Understanding these intricate relationships paves the way for novel therapeutic targets to ameliorate neurodegenerative symptoms and enhance overall brain health. </span></span></span><br> &nbsp;</div> Gut-Brain Axis, Alzheimer's, Huntington's, Parkinson's 108 121 http://neuroupdates.de/browse.php?a_code=A-10-1-52&slc_lang=en&sid=1 Al-Hassan Soliman Wadan Alhassan.soliman.168@gmail.com 1003194753284600312 1003194753284600312 Yes Department of Oral Biology, Faculty of Dentistry, Galala University, Suez, Egypt Dana Saeed El-Gemaie 1003194753284600313 1003194753284600313 No Department of Endodontics, Faculty of Dentistry, Galala University, Suez, Egypt Mohamed Abdelsattar Ahmed 1003194753284600314 0009-0004-7951-9231 No Faculty of Dentistry, Sinai University, Kantara Branch, Ismailia, Egypt