en Clinical Neuroscience Clinical Neuroscience Original Article <h4 style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span new="" roman="" times="">Chronic stress during the pre-pubertal period has adverse effects in developing neuropsychiatric disorders such as depression and anxiety. The administration of supplements with antioxidant properties may alleviate depression and anxiety behavior. This study investigated the effects of oral supplementation of Japanese sake yeast on anxiety, depressive-like symptoms, oxidative stress, and changes in brain-derived neurotropic factor (BDNF) in adolescence rats subjected to chronic stress. In order to assess the effects of chronic stress, adolescent rats were grouped into one non-stressed control group (non-stress) and four different experimental groups. The other animals were subjected to stress and orally received normal saline (Control-stress), 15 mg/kg yeast (Stress-15), 30 mg/kg yeast (Stress-30) and 45 mg/kg yeast (Stress-45). Anxiety and depression-like behavior, BDNF levels, and oxidative stress markers were evaluated. The rats exposed to stress exhibited anxiogenic and depression-like behavior as well as lower levels of BDNF and higher levels of oxidative markers compared with non-stressed rats (<i>P</i><0.05). However, the oral supplementation of sake yeast decreased anxiogenic and depression-like behavior and oxidative indices, and also increased BDNF levels compared to stressed rats treated with saline in a dose-dependent manner (<i>P</i><0.05). In sum, stress caused anxiety and depression behavior, increased oxidative indices, and reduced BDNF levels while sake yeast alleviated adverse effects of stress on anxiety and depression behaviors, decreased oxidative markers, and increased BDNF levels.&nbsp;</span></span></span></span></h4> Anxiety, BDNF, Depression, Oxidative markers, Rat model, Sake yeast 1 8 http://neuroupdates.de/browse.php?a_code=A-10-302-2&slc_lang=en&sid=1 Motahareh Haghipanah 1003194753284600334 1003194753284600334 No International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia Maryam Saadat 1003194753284600335 1003194753284600335 No Department of Anatomical Sciences, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran Asal Safarbalou 1003194753284600336 1003194753284600336 No International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia Thomas Budde 1003194753284600337 1003194753284600337 No Institut für Physiologie I, Westfälische Wilhelms-Universität, Münster, Germany Wael Mohamed 1003194753284600338 1003194753284600338 No Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Pahang, Malaysia Elham Sadat Afraz 1003194753284600339 1003194753284600339 Yes Department of Oral Medicine, School of Dentistry, Semnan University of Medical Sciences, Semnan, Iran Nasrollah Moradikor 1003194753284600340 1003194753284600340 No International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia