Life Neuroscience

1. Teleanu, D. M., Niculescu, A. G., Lungu, I. I., Radu, C. I., Vladâcenco, O., Roza, E., & Teleanu, R. I. (2022). An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. International journal of molecular sciences, 23(11), 5938. [DOI:10.3390/ijms23115938] [PMID] [PMCID]

2. Gilgun-Sherki, Y., Melamed, E., & Offen, D. (2001). Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology, 40(8), 959-975. [DOI:10.1016/S0028-3908(01)00019-3] [PMID]

3. Shacham, T., Sharma, N., & Lederkremer, G. Z. (2019). Protein misfolding and ER stress in Huntington's disease. Frontiers in molecular biosciences, 6, 20. [DOI:10.3389/fmolb.2019.00020] [PMID] [PMCID]

4. Kovarik, Z., Moshitzky, G., Maček Hrvat, N., & Soreq, H. (2024). Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults. Journal of neurochemistry, 168(4), 355-369. [DOI:10.1111/jnc.15887] [PMID]

5. Pyatha, S., Kim, H., Lee, D., & Kim, K. (2022). Association between heavy metal exposure and Parkinson's disease: a review of the mechanisms related to oxidative stress. Antioxidants, 11(12), 2467. [DOI:10.3390/antiox11122467] [PMID] [PMCID]

6. Hassamal, S. (2023). Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories. Frontiers in psychiatry, 14, 1130989. [DOI:10.3389/fpsyt.2023.1130989] [PMID] [PMCID]

7. Li, J., Tong, L., Schock, B. C., & Ji, L. L. (2023). Post-traumatic stress disorder: focus on neuroinflammation. Molecular Neurobiology, 60(7), 3963-3978. [DOI:10.1007/s12035-023-03320-z] [PMID]

8. Zeng, J., Lu, Y., Chu, H., Lu, L., Chen, Y., Ji, K., ... & Wang, S. (2024). Research trends and frontier hotspots of TRPV1 based on bibliometric and visualization analyses. Heliyon. [DOI:10.1016/j.heliyon.2024.e24153]

9. Jurcău, M. C., Andronie-Cioara, F. L., Jurcău, A., Marcu, F., Ţiț, D. M., Pașcalău, N., & Nistor-Cseppentö, D. C. (2022). The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of Alzheimer's disease: therapeutic implications and future perspectives. Antioxidants, 11(11), 2167. [DOI:10.3390/antiox11112167] [PMID] [PMCID]

10. Amidfar, M., de Oliveira, J., Kucharska, E., Budni, J., & Kim, Y. K. (2020). The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease. Life sciences, 257, 118020. [DOI:10.1016/j.lfs.2020.118020] [PMID]

11. Kisby, G. E., Wilson III, D. M., & Spencer, P. S. (2024). Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders. International journal of molecular sciences, 25(13), 7221. [DOI:10.3390/ijms25137221] [PMID] [PMCID]

12. Clemente-Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Ramos-Campo, D. J., Belinchón-deMiguel, P., Martinez-Guardado, I., ... & Tornero-Aguilera, J. F. (2023). Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities. Biomedicines, 11(9), 2488. [DOI:10.3390/biomedicines11092488] [PMID] [PMCID]

13. Takahashi, S., & Mashima, K. (2022). Neuroprotection and disease modification by astrocytes and microglia in Parkinson disease. Antioxidants, 11(1), 170. [DOI:10.3390/antiox11010170] [PMID] [PMCID]

14. Ji, N., Lei, M., Chen, Y., Tian, S., Li, C., & Zhang, B. (2023). How oxidative stress induces depression?. ASN neuro, 15, 17590914231181037. [DOI:10.1177/17590914231181037] [PMID] [PMCID]

15. Tchekalarova, J., & Tzoneva, R. (2023). Oxidative stress and aging as risk factors for Alzheimer's disease and Parkinson's disease: the role of the antioxidant melatonin. International journal of molecular sciences, 24(3), 3022. [DOI:10.3390/ijms24033022] [PMID] [PMCID]

16. Zhang, S., Hu, J., Liu, G., Wu, H., Li, M., Shi, C., ... & Li, W. (2022). Chronic clomipramine treatment increases hippocampal volume in rats exposed to chronic unpredictable mild stress. Translational Psychiatry, 12(1), 245. [DOI:10.1038/s41398-022-02006-9] [PMID] [PMCID]

17. Xia, Z. D., Ma, R. X., Wen, J. F., Zhai, Y. F., Wang, Y. Q., Wang, F. Y., & Zheng, X. H. (2023). Pathogenesis, Animal Models, and Drug Discovery of Alzheimer's Disease. Journal of Alzheimer's Disease, (Preprint), 1-37. [DOI:10.3233/JAD-230326] [PMID]

18. Yu, Y., Chen, R., Mao, K., Deng, M., & Li, Z. (2024). The Role of Glial Cells in Synaptic Dysfunction: Insights into Alzheimer's Disease Mechanisms. Aging and Disease, 15(2), 459. [DOI:10.14336/AD.2023.0718] [PMID]

19. Reynolds, A., Laurie, C., Mosley, R. L., & Gendelman, H. E. (2007). Oxidative stress and the pathogenesis of neurodegenerative disorders. International review of neurobiology, 82, 297-325. [DOI:10.1016/S0074-7742(07)82016-2] [PMID]

20. Zhang, Y., Yang, Y., Li, H., Feng, Q., Ge, W., & Xu, X. (2024). Investigating the potential mechanisms and therapeutic targets of inflammatory cytokines in post-stroke depression. Molecular Neurobiology, 61(1), 132-147. [DOI:10.1007/s12035-023-03563-w] [PMID]

21. Bisht, K., Sharma, K., & Tremblay, M. È. (2018). Chronic stress as a risk factor for Alzheimer's disease: roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress. Neurobiology of stress, 9, 9-21. [DOI:10.1016/j.ynstr.2018.05.003] [PMID] [PMCID]

22. Weber, J. T. (2004). Calcium homeostasis following traumatic neuronal injury. Current neurovascular research, 1(2), 151-171. [DOI:10.2174/1567202043480134] [PMID]

23. Guo, L., Tian, J., & Du, H. (2017). Mitochondrial dysfunction and synaptic transmission failure in Alzheimer's disease. Journal of Alzheimer's Disease, 57(4), 1071-1086. [DOI:10.3233/JAD-160702] [PMID] [PMCID]

24. Jha, S. K., Jha, N. K., Kumar, D., Ambasta, R. K., & Kumar, P. (2017). Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(5), 1132-1146. [DOI:10.1016/j.bbadis.2016.06.015] [PMID]

25. Amiri, Bita, Maryam Yazdani Tabrizi, Mahdyieh Naziri, Farzaneh Moradi, Mohammadreza Arzaghi, Iman Archin, Fatemeh Behaein et al. "Neuroprotective effects of Flavonoids: Endoplasmic reticulum as the target." Frontiers in Neuroscience 18 (2024): 1348151. [DOI:10.3389/fnins.2024.1348151] [PMID] [PMCID]

26. Hassan, Syed Shams ul, Saptadip Samanta, Raju Dash, Tomasz M. Karpiński, Emran Habibi, Abdul Sadiq, Amirhossein Ahmadi, and Simona Bungau. "The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress." Frontiers in Pharmacology 13 (2022): 1015835. [DOI:10.3389/fphar.2022.1015835] [PMID]

27. Jurcau, A. (2021). Insights into the pathogenesis of neurodegenerative diseases: Focus on mitochondrial dysfunction and oxidative stress. International journal of molecular sciences, 22(21), 11847. [DOI:10.3390/ijms222111847] [PMID] [PMCID]

28. Stone, D. K., Reynolds, A. D., Mosley, R. L., & Gendelman, H. E. (2009). Innate and adaptive immunity for the pathobiology of Parkinson's disease. Antioxidants & redox signaling, 11(9), 2151-2166. [DOI:10.1089/ars.2009.2460] [PMID] [PMCID]

29. San-Millán, I. (2023). The key role of mitochondrial function in health and disease. Antioxidants, 12(4), 782. [DOI:10.3390/antiox12040782] [PMID] [PMCID]

30. Babbar, M., & Sheikh, M. S. (2013). Metabolic stress and disorders related to alterations in mitochondrial fission or fusion. Molecular and cellular pharmacology, 5(3), 109.

31. Mehan, S., Kaur, G., Dudi, R., Rajput, M., & Kalra, S. (2017). Restoration of mitochondrial dysfunction in 6-hydroxydopamine induced Parkinson's disease: a complete review. Open Journal of Parkinson's Disease and Treatment, 1(1), 001-026. [DOI:10.17352/ojpdt.000001]

32. Liu, L., Wu, J., Zhang, C., Cao, T., Lu, Y., He, Z., & Li, Z. (2024). Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice. Brain Research, 1835, 148930. [DOI:10.1016/j.brainres.2024.148930] [PMID]

33. Milisav, I., Šuput, D., & Ribarič, S. (2015). Unfolded protein response and macroautophagy in Alzheimer's, Parkinson's and prion diseases. Molecules, 20(12), 22718-22756. [DOI:10.3390/molecules201219865] [PMID] [PMCID]

34. Cui, X., Zhang, Y., Lu, Y., & Xiang, M. (2022). ROS and endoplasmic reticulum stress in pulmonary disease. Frontiers in Pharmacology, 13, 879204. [DOI:10.3389/fphar.2022.879204] [PMID] [PMCID]

35. Kam, M. K., Kim, B., Lee, D. G., Lee, H. J., Park, Y. H., & Lee, D. S. (2022). Amyloid beta oligomers-induced parkin aggravates ER stress-mediated cell death through a positive feedback loop. Neurochemistry International, 155, 105312. [DOI:10.1016/j.neuint.2022.105312] [PMID]

36. Wolozin, B. (2012). Regulated protein aggregation: stress granules and neurodegeneration. Molecular neurodegeneration, 7, 1-12. [DOI:10.1186/1750-1326-7-56] [PMID] [PMCID]

37. Dou, Y., & Zhao, D. (2022). Targeting Emerging Pathogenic Mechanisms by Natural Molecules as Potential Therapeutics for Neurodegenerative Diseases. Pharmaceutics, 14(11), 2287. [DOI:10.3390/pharmaceutics14112287] [PMID] [PMCID]

38. Wodrich, A. P., Scott, A. W., Shukla, A. K., Harris, B. T., & Giniger, E. (2022). The unfolded protein responses in health, aging, and neurodegeneration: recent advances and future considerations. Frontiers in molecular neuroscience, 15, 831116. [DOI:10.3389/fnmol.2022.831116] [PMID] [PMCID]

39. Milicic, L., Porter, T., Vacher, M., & Laws, S. M. (2023). Utility of DNA Methylation as a Biomarker in Aging and Alzheimer's Disease. Journal of Alzheimer's Disease Reports, 7(1), 475-503. [DOI:10.3233/ADR-220109] [PMID] [PMCID]

40. Brembati, V., Faustini, G., Longhena, F., & Bellucci, A. (2023). Alpha synuclein post translational modifications: potential targets for Parkinson's disease therapy? Frontiers in molecular neuroscience, 16, 1197853. [DOI:10.3389/fnmol.2023.1197853] [PMID] [PMCID]

41. Moore, B. D. (2015). Transcriptional regulation of the endoplasmic reticulum in dedicated secretory cells. Washington University in St. Louis.

42. Cui, Q., Liu, Z., & Bai, G. (2024). Friend or foe: The role of stress granule in neurodegenerative disease. Neuron. [DOI:10.1016/j.neuron.2024.04.025] [PMCID]

43. A. Armstrong, R. (2019). Risk Factors for Alzheimer's Disease. Folia Neuropathologica, 57(2), 87-105. [DOI:10.5114/fn.2019.85929] [PMID]

44. Henderson, A. S. (1988). The risk factors for Alzheimer's disease: a review and a hypothesis. Acta Psychiatrica Scandinavica, 78(3), 257-275. [DOI:10.1111/j.1600-0447.1988.tb06336.x] [PMID]

45. Pedersen, W. (2001). Impact of aging on stress-responsive neuroendocrine systems. Mechanisms of Ageing and Development, 122(9), 963-983. [DOI:10.1016/S0047-6374(01)00250-0] [PMID]

46. Du, X., & Pang, T. Y. (2015a, February 16). Is dysregulation of the hpa-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases? Frontiers. [DOI:10.3389/fpsyt.2015.00032] [PMID] [PMCID]

47. Michael Caudle, W. (2016). This can't be stressed enough: The contribution of select environmental toxicants to disruption of the stress circuitry and response. Physiology & Behavior, 166, 65-75. [DOI:10.1016/j.physbeh.2015.09.021] [PMID] [PMCID]

48. Justice, N. J. (2018). The relationship between stress and Alzheimer's disease. Neurobiology of Stress, 8(1), 127-133. [DOI:10.1016/j.ynstr.2018.04.002] [PMID] [PMCID]

49. Ray, B., Gaskins, D. L., Sajdyk, T. J., Spence, J. P., Fitz, S. D., Shekhar, A., & Lahiri, D. K. (2011). Restraint stress and repeated corticotrophin-releasing factor receptor activation in the amygdala both increase amyloid-β precursor protein and amyloid-β peptide but have divergent effects on brain-derived neurotrophic factor and pre-synaptic proteins in the prefrontal cortex of rats. Neuroscience, 184, 139-150. [DOI:10.1016/j.neuroscience.2011.03.067] [PMID] [PMCID]

50. Briones, A., Gagno, S., Martisova, E., Dobarro, M., Aisa, B., Solas, M., Tordera, R., & Ramírez, M. (2012). Stress-induced anhedonia is associated with an increase in Alzheimer's disease-related markers. British Journal of Pharmacology, 165(4), 897-907. [DOI:10.1111/j.1476-5381.2011.01602.x] [PMID] [PMCID]

51. Justice, N. J., Huang, L., Tian, J.-B. ., Cole, A., Pruski, M., Hunt, A. J., Flores, R., Zhu, M. X., Arenkiel, B. R., & Zheng, H. (2015). Posttraumatic Stress Disorder-Like Induction Elevates -Amyloid Levels, Which Directly Activates Corticotropin-Releasing Factor Neurons to Exacerbate Stress Responses. Journal of Neuroscience, 35(6), 2612-2623. [DOI:10.1523/JNEUROSCI.3333-14.2015] [PMID] [PMCID]

52. Lesuis, S. L., Maurin, H., Borghgraef, P., Lucassen, P. J., Fred Van Leuven, & Krugers, H. J. (2016). Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease. Oncotarget, 7(26), 39118-39135. [DOI:10.18632/oncotarget.9776] [PMID] [PMCID]

53. Green, K. N. (2006). Glucocorticoids Increase Amyloid-beta and Tau Pathology in a Mouse Model of Alzheimer's Disease. Journal of Neuroscience, 26(35), 9047-9056. [DOI:10.1523/JNEUROSCI.2797-06.2006] [PMID] [PMCID]

54. Sotiropoulos, I., Catania, C., Pinto, L. G., Silva, R., Pollerberg, G. E., Takashima, A., Sousa, N., & Almeida, O. F. X. (2011). Stress Acts Cumulatively to Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits. Journal of Neuroscience, 31(21), 7840-7847. [DOI:10.1523/JNEUROSCI.0730-11.2011] [PMID] [PMCID]

55. Smith, L. K., Jadavji, N. M., Colwell, K. L., Katrina Perehudoff, S., & Metz, G. A. (2008). Stress accelerates neural degeneration and exaggerates motor symptoms in a rat model of Parkinson's disease. European Journal of Neuroscience, 27(8), 2133-2146. [DOI:10.1111/j.1460-9568.2008.06177.x] [PMID] [PMCID]

56. Rasheed, N., Ahmad, A., Pandey, C. P., Chaturvedi, R. K., Lohani, M., & Palit, G. (2009). Differential Response of Central Dopaminergic System in Acute and Chronic Unpredictable Stress Models in Rats. Neurochemical Research, 35(1), 22-32. [DOI:10.1007/s11064-009-0026-5] [PMID]

57. Wu, Q., Yang, X., Zhang, Y., Zhang, L., & Feng, L. (2016). Chronic mild stress accelerates the progression of Parkinson's disease in A53T α-synuclein transgenic mice. 285, 61-71. [DOI:10.1016/j.expneurol.2016.09.004] [PMID]

58. Kim, S. R., Kim, J. Y., Kim, H. K., Lim, K. E., Kim, M. S., & Chung, S. J. (2017). Association among type D personality, non-motor symptoms, and quality of life in Parkinson's disease: A cross-sectional study. Geriatric Nursing, 38(5), 431-436. [DOI:10.1016/j.gerinurse.2017.02.006] [PMID]

59. Gerhard, A., Pavese, N., Hotton, G., Turkheimer, F., Es, M., Hammers, A., Eggert, K., Oertel, W., Banati, R. B., & Brooks, D. J. (2006). In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiology of Disease, 21(2), 404-412. [DOI:10.1016/j.nbd.2005.08.002] [PMID] [PMCID]

60. Depino, A. M., Earl, C., Kaczmarczyk, E., Ferrari, C., Besedovsky, H., del Rey, A., Pitossi, F. J., & Oertel, W. H. (2003). Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease. European Journal of Neuroscience, 18(10), 2731-2742. [DOI:10.1111/j.1460-9568.2003.03014.x] [PMID]

61. Kim, S. T., Choi, J. H., Chang, J. W., Kim, S. W., & Hwang, O. (2005). Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuromelanin and oxidative damage in the nigrostriatal system. Journal of Neurochemistry, 95(1), 89-98. [DOI:10.1111/j.1471-4159.2005.03342.x] [PMID]

62. Tobón-Velasco, J. C., Limón-Pacheco, J. H., Orozco-Ibarra, M., Macías-Silva, M., Vázquez-Victorio, G., Cuevas, E., Ali, S. F., Cuadrado, A., José Pedraza-Chaverri, & Santamaría, A. (2013). RETRACTED: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors. Toxicology, 304, 109-119. [DOI:10.1016/j.tox.2012.12.011] [PMID]

63. Teismann, P., Tieu, K., Choi, D.-K. ., Wu, D.-C. ., Naini, A., Hunot, S., Vila, M., Jackson-Lewis, V., & Przedborski, S. (2003). Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proceedings of the National Academy of Sciences, 100(9), 5473-5478. [DOI:10.1073/pnas.0837397100] [PMID] [PMCID]

64. Lin, T.-K., Cheng, C.-H., Chen, S.-D., Liou, C.-W., Huang, C.-R., & Chuang, Y.-C. (2012). Mitochondrial Dysfunction and Oxidative Stress Promote Apoptotic Cell Death in the Striatum via Cytochrome c/ Caspase-3 Signaling Cascade Following Chronic Rotenone Intoxication in Rats. International Journal of Molecular Sciences, 13(7), 8722-8739. [DOI:10.3390/ijms13078722] [PMID] [PMCID]

65. Lucca, G., Comim, C. M., Valvassori, S. S., Réus, G. Z., Vuolo, F., Petronilho, F., Dal-Pizzol, F., Gavioli, E. C., & Quevedo, J. (2009). Effects of chronic mild stress on the oxidative parameters in the rat brain. Neurochemistry International, 54(5-6), 358-362. [DOI:10.1016/j.neuint.2009.01.001] [PMID]

66. Goldstein, D. (2011). Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases. Endocrine Regulations, 45(2), 91-98. [DOI:10.4149/endo_2011_02_91] [PMID] [PMCID]

67. Dufour, B. D., & McBride, J. L. (2016). Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease. Experimental Neurology, 283, 308-317. [DOI:10.1016/j.expneurol.2016.06.028] [PMID] [PMCID]

68. Scarpa, J. R., Jiang, P., Bojan Losic, Readhead, B., Gao, V. D., Dudley, J. T., Vitaterna, M. H., Turek, F. W., & Kasarskis, A. (2016). Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington's Disease. PLOS Genetics, 12(7), e1006137-e1006137. [DOI:10.1371/journal.pgen.1006137] [PMID] [PMCID]

69. Mo, C., Renoir, T., & Hannan, A. J. (2014). Effects of chronic stress on the onset and progression of Huntington's disease in transgenic mice. Neurobiology of Disease, 71, 81-94. [DOI:10.1016/j.nbd.2014.07.008] [PMID]

70. Al-Chalabi, A., & Hardiman, O. (2013). The epidemiology of ALS: a conspiracy of genes, environment and time. Nature Reviews Neurology, 9(11), 617-628. [DOI:10.1038/nrneurol.2013.203] [PMID]

71. Chio, A. (2005). Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain, 128(3), 472-476. [DOI:10.1093/brain/awh373] [PMID] [PMCID]

72. Lehman, E. J., Hein, M. J., Baron, S. L., & Gersic, C. M. (2012). Neurodegenerative causes of death among retired National Football League players. Neurology, 79(19), 1970-1974. [DOI:10.1212/WNL.0b013e31826daf50] [PMID] [PMCID]

73. Lu, C., & Xu, X. (2023). The Role of Stress in the Progression of Motor Neuron Disease: Mechanisms and Implications for Treatment. Stress and Brain, 3(4), 159-178. [DOI:10.26599/SAB.2023.9060002]

74. Smith, S. M., & Vale, W. W. (2006). The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues in Clinical Neuroscience, 8(4), 383-395. [DOI:10.31887/DCNS.2006.8.4/ssmith] [PMID]

75. Nicolaides, N. C., Kyratzi, E., Lamprokostopoulou, A., Chrousos, G. P., & Charmandari, E. (2015). Stress, the Stress System and the Role of Glucocorticoids. Neuroimmunomodulation, 22(1-2), 6-19. [DOI:10.1159/000362736] [PMID]

76. Minagawa, K., Yamada, S., Suzuki, A., Ta, S., Kumai, T., Lambein, F., & Kusama-Eguchi, K. (2019). Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats. Environmental Toxicology and Pharmacology, 72, 103245. [DOI:10.1016/j.etap.2019.103245] [PMID]

77. Dong, H., & Csernansky, J. G. (2009). Effects of Stress and Stress Hormones on Amyloid-β Protein and Plaque Deposition. Journal of Alzheimer's Disease, 18(2), 459-469. [DOI:10.3233/JAD-2009-1152] [PMID] [PMCID]

78. REGAN, R. F., & GUO, Y. (1998). Toxic Effect of Hemoglobin on Spinal Cord Neurons in Culture. Journal of Neurotrauma, 15(8), 645-653. [DOI:10.1089/neu.1998.15.645] [PMID]

79. Goadsby, P. J. (2018). Migraine and Other Primary Headache Disorders (J. L. Jameson, A. S. Fauci, D. L. Kasper, S. L. Hauser, D. L. Longo, & J. Loscalzo, Eds.). Access Medicine; McGraw-Hill Education.

80. Stubberud, A., Buse, D. C., Kristoffersen, E. S., Linde, M., & Tronvik, E. (2021). Is there a causal relationship between stress and migraine? Current evidence and implications for management. The Journal of Headache and Pain, 22(1). [DOI:10.1186/s10194-021-01369-6] [PMID] [PMCID]

81. Malik, M. (2017, June 16). Correlation of stress with migraine: a review. ResearchGate; Dr. Yashwant Research Labs Pvt. Ltd.

82. Theeler, B. J., Kenney, K., Prokhorenko, O. A., Fideli, U. S., Campbell, W., & Erickson, J. C. (2010). Headache triggers in the US military. Headache, 50(5), 790-794. [DOI:10.1111/j.1526-4610.2009.01571.x] [PMID]

83. Dodick, D. (2009). Review of comorbidities and risk factors for the development of migraine complications (infarct and chronic migraine). Cephalalgia, 29, 7-14. [DOI:10.1111/j.1468-2982.2009.02028.x] [PMID]

84. Hedborg, K., Anderberg, U. M., & Muhr, C. (2011). Stress in migraine: personality-dependent vulnerability, life events, and gender are of significance. Upsala Journal of Medical Sciences, 116(3), 187-199. [DOI:10.3109/03009734.2011.573883] [PMID] [PMCID]

85. Sauro, K. M., & Becker, W. J. (2009). The Stress and Migraine Interaction. Headache: The Journal of Head and Face Pain, 49(9), 1378-1386. [DOI:10.1111/j.1526-4610.2009.01486.x] [PMID]

86. Domanskyi, A., & Parlato, R. (2022). Oxidative Stress in Neurodegenerative Diseases. Antioxidants, 11(3), 504. [DOI:10.3390/antiox11030504] [PMID] [PMCID]

87. Uttara, B., Singh, A. V., Zamboni, P., & Mahajan, R. T. (2009). Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options. Current Neuropharmacology, 7(1), 65-74. [DOI:10.2174/157015909787602823] [PMID] [PMCID]

88. Komaki, H., Faraji, N., Komaki, A., Shahidi, S., Etaee, F., Raoufi, S., & Mirzaei, F. (2019). Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer's disease. Brain Research Bulletin, 147, 14-21. [DOI:10.1016/j.brainresbull.2019.01.025] [PMID]

89. Dhami, M., Raj, K., & Singh, S. (2021). Neuroprotective Effect of Fucoxanthin against Intracerebroventricular Streptozotocin (ICV-STZ) Induced Cognitive Impairment in Experimental Rats. Current Alzheimer Research, 18(8), 623-637. [DOI:10.2174/1567205018666211118144602] [PMID]

90. Hira, S., Saleem, U., Anwar, F., Sohail, M. F., Raza, Z., & Ahmad, B. (2019). β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer's Disease. Biomolecules, 9(9). [DOI:10.3390/biom9090441] [PMID] [PMCID]

91. Cordaro, M., Salinaro, A. T., Siracusa, R., D'Amico, R., Impellizzeri, D., Scuto, M., Ontario, M. L., Cuzzocrea, S., Di Paola, R., Fusco, R., & Calabrese, V. (2021). Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer's Disease. Antioxidants, 10(11), 1664. [DOI:10.3390/antiox10111664] [PMID] [PMCID]

92. Kushairi, N., Phan, C. W., Sabaratnam, V., David, P., & Naidu, M. (2019). Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia. Antioxidants, 8(8), 261. [DOI:10.3390/antiox8080261] [PMID] [PMCID]

93. Wang, H., Jiang, T., Li, W., Gao, N., & Zhang, T. (2018). Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer's disease. 282, 100-108. [DOI:10.1016/j.toxlet.2017.10.021] [PMID]

94. Khan, M. S., Muhammad, T., Ikram, M., & Kim, M. O. (2019). Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-κB/Akt Signaling Pathway in Adult Rats. Oxidative Medicine and Cellular Longevity, 2019, 1-23. [DOI:10.1155/2019/7860650] [PMID]

95. Frontiñán-Rubio, J., Sancho-Bielsa, F. J., Peinado, J. R., LaFerla, F. M., Giménez-Llort, L., Durán-Prado, M., & Alcaín, F. J. (2018). Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease. 92, 67-81. [DOI:10.1016/j.mcn.2018.06.005] [PMID]

96. Ibrahim Fouad, G. (2020). Combination of Omega 3 and Coenzyme Q10 Exerts Neuroprotective Potential Against Hypercholesterolemia-Induced Alzheimer's-Like Disease in Rats. Neurochemical Research, 45(5), 1142-1155. [DOI:10.1007/s11064-020-02996-2] [PMID]

97. Therapeutics, D. of *Medicine and. (n.d.). Six-month randomized, placebo-controlled, double-blind: Journal of Clinical Psychopharmacology. LWW.

98. Moussa, C., Hebron, M., Huang, X., Ahn, J., Rissman, R. A., Aisen, P. S., & Turner, R. S. (2017). Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease. Journal of Neuroinflammation, 14(1). [DOI:10.1186/s12974-016-0779-0] [PMID] [PMCID]

99. Lloret, A., Esteve, D., Monllor, P., Cervera-Ferri, A., & Lloret, A. (2019). The Effectiveness of Vitamin E Treatment in Alzheimer's Disease. International Journal of Molecular Sciences, 20(4), 879. [DOI:10.3390/ijms20040879] [PMID] [PMCID]

100. Dong, Y., Chen, X., Liu, Y., Shu, Y., Chen, T., Xu, L., Li, M., & Guan, X. (2017). Do low-serum vitamin E levels increase the risk of Alzheimer disease in older people? Evidence from a meta-analysis of case-control studies. International Journal of Geriatric Psychiatry, 33(2), e257-e263. [DOI:10.1002/gps.4780]

101. Casati, M., Boccardi, V., Ferri, E., Bertagnoli, L., Bastiani, P., Ciccone, S., Mansi, M., Scamosci, M., Rossi, P. D., Mecocci, P., & Arosio, B. (2019). Vitamin E and Alzheimer's disease: the mediating role of cellular aging. Aging Clinical and Experimental Research, 32(3), 459-464. [DOI:10.1007/s40520-019-01209-3] [PMID]

102. Kandiah, N., Ong, P. A., Yuda, T., Ng, L.-L., Mamun, K., Merchant, R. A., Chen, C., Dominguez, J., Marasigan, S., Ampil, E., Nguyen, V. T., Yusoff, S., Chan, Y. F., Yong, F. M., Krairit, O., Suthisisang, C., Senanarong, V., Ji, Y., Thukral, R., & Ihl, R. (2019). Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761®. CNS Neuroscience & Therapeutics, 25(2), 288-298. [DOI:10.1111/cns.13095] [PMID] [PMCID]

103. Cowan, C. M., Sealey, M. A., & Mudher, A. (2020). Suppression of tau‐induced phenotypes by vitamin E demonstrates the dissociation of oxidative stress and phosphorylation in mechanisms of tau toxicity. Journal of Neurochemistry, 157(3), 684-694. [DOI:10.1111/jnc.15253] [PMID]

104. Zhou, J., Zhang, S., Zhao, X., & Wei, T. (2008). Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-β1-42. Journal of Pineal Research, 45(2), 157-165. [DOI:10.1111/j.1600-079X.2008.00570.x] [PMID]

105. Deng, Y., Xu, G., Duan, P., Zhang, Q., & Wang, J. (2005). Effects of melatonin on wortmannin-induced tau hyperphosphorylation. Acta Pharmacologica Sinica, 26(5), 519-526. [DOI:10.1111/j.1745-7254.2005.00102.x] [PMID]

106. Tripathi, S., Kumari, U., & Mitra Mazumder, P. (2020). Ameliorative effects of apple cider vinegar on neurological complications via regulation of oxidative stress markers. Journal of Food Biochemistry, 44(12). [DOI:10.1111/jfbc.13504] [PMID]

107. Burgener, S. C., Buettner, L., Buckwalter, K. C., Beattie, E., Bossen, A. L., Fick, D. M., Fitzsimmons, S., Kolanowski, A., Richeson, N. E., Rose, K., Schreiner, A., Specht, J. K. P., Testad, I., Yu, F., & Mckenzie, S. (2008). Evidence supporting nutritional interventions for persons in early stage Alzheimer's disease (AD). The Journal of Nutrition Health and Aging, 12(1), 18-21. [DOI:10.1007/BF02982159] [PMID] [PMCID]

108. Francesco De Nuccio, Cianciulli, A., Porro, C., Kashyrina, M., Ruggiero, M., Calvello, R., Miraglia, A., Nicolardi, G., Dario Domenico Lofrumento, & Maria Antonietta Panaro. (2021). Inflammatory Response Modulation by Vitamin C in an MPTP Mouse Model of Parkinson's Disease. Biology, 10(11), 1155-1155. [DOI:10.3390/biology10111155] [PMID] [PMCID]

109. Zeng, X., Xu, K., Wang, J., Xu, Y., & Qu, S. (2020). Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF-κB Signaling. Neural Plasticity, 2020, 1-14. [DOI:10.1155/2020/8872296] [PMID] [PMCID]

110. Zhang, Q., Yang, C., Liu, T., Liu, L., Li, F., Cai, Y., Lv, K., Li, X., Gao, J., Sun, D., Xu, H., Yang, Q., & Fan, X. (2018). Citalopram restores short-term memory deficit and non-cognitive behaviors in APP/PS1 mice while halting the advance of Alzheimer's disease-like pathology. Neuropharmacology, 131, 475-486. [DOI:10.1016/j.neuropharm.2017.12.021] [PMID]

111. Wu, W., Han, H., Liu, J., Tang, M., Wu, X., Cao, X., Zhao, T., Lu, Y., Niu, T., Chen, J., & Chen, H. (2021). Fucoxanthin Prevents 6-OHDA-Induced Neurotoxicity by Targeting Keap1. Oxidative Medicine and Cellular Longevity, 2021, 1-14. [DOI:10.1155/2021/6688708] [PMID] [PMCID]

112. Pharmacology, 1 Department of (2020) Neuroprotective potential of quercetin in combination with.Neural regeneration research, LWW.

113. Mischley, L. K., Lau, R. C., Shankland, E. G., Wilbur, T. K., & Padowski, J. M. (16 C.E.). Phase IIb Study of Intranasal Glutathione in Parkinson's Disease. Journal of Parkinson's Disease, 7(2), 289-299. [DOI:10.3233/JPD-161040] [PMID] [PMCID]

114. Seet, R. C.-S., Lim, E. C. H., Tan, J. J. H., Quek, A. M. L., Chow, A. W. L., Chong, W.-L., Ng, M. P. E., Ong, C.-N., & Halliwell, B. (2014). Does High-Dose Coenzyme Q10 Improve Oxidative Damage and Clinical Outcomes in Parkinson's Disease? Antioxidants & Redox Signaling, 21(2), 211-217. [DOI:10.1089/ars.2013.5801] [PMID]

115. Khan, F., Kumar Garg, V., Kumar Singh, A., & Tinku, T. (2018). Role of free radicals and certain antioxidants in the management of huntington's disease: a review. Journal of Analytical & Pharmaceutical Research, 7(4). [DOI:10.15406/japlr.2018.07.00256]

116. Petri, S., Körner, S., & Kiaei, M. (2012). Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS. Neurology Research International, 2012, 1-7. [DOI:10.1155/2012/878030] [PMID] [PMCID]

117. Kumar, P., & Kumar, A. (2010). Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: Possible role of nitric oxide. Behavioural Brain Research, 206(1), 38-46. [DOI:10.1016/j.bbr.2009.08.028] [PMID]

118. Richetti, S. K., Blank, M., Capiotti, K. M., Piato, A. L., Bogo, M. R., Vianna, M. R., & Bonan, C. D. (2011). Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish. Behavioural Brain Research, 217(1), 10-15. [DOI:10.1016/j.bbr.2010.09.027] [PMID]

119. Menze, E. T., Tadros, M. G., Abdel-Tawab, A. M., & Khalifa, A. E. (2012). Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats. NeuroToxicology, 33(5), 1265-1275. [DOI:10.1016/j.neuro.2012.07.007] [PMID]

120. Polyzos, A., Holt, A., Brown, C., Cosme, C., Wipf, P., Gomez-Marin, A., Castro, M. R., Ayala-Peña, S., & McMurray, C. T. (2016). Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes. Human Molecular Genetics, 25(9), 1792-1802. [DOI:10.1093/hmg/ddw051] [PMID] [PMCID]

121. Chabrier, P. E., & Auguet, M. (2007). Pharmacological Properties of BN82451: A Novel Multitargeting Neuroprotective Agent. CNS Drug Reviews, 13(3), 317-332. [DOI:10.1111/j.1527-3458.2007.00018.x] [PMID] [PMCID]

122. Beretta, S., Sala, G., Mattavelli, L., Ceresa, C., Casciati, A., Ferri, A., Maria Teresa Carrı̀, & Ferrarese, C. (2003). Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine. Neurobiology of Disease, 13(3), 213-221. [DOI:10.1016/S0969-9961(03)00043-3] [PMID]

123. Olufunmilayo, E. O., Gerke-Duncan, M. B., & Holsinger, R. M. D. (2023). Oxidative Stress and Antioxidants in Neurodegenerative Disorders. Antioxidants, 12(2), 517. [DOI:10.3390/antiox12020517] [PMID] [PMCID]

124. Wang, H., O'Reilly, E. J., Weisskopf, M. G., Logroscino, G., McCullough, M. L., Schatzkin, A., Kolonel, L. N., & Ascherio, A. (2011). Vitamin E Intake and Risk of Amyotrophic Lateral Sclerosis: A Pooled Analysis of Data From 5 Prospective Cohort Studies. American Journal of Epidemiology, 173(6), 595-602. [DOI:10.1093/aje/kwq416] [PMID] [PMCID]

125. Freedman, D. M., Kuncl, R. W., Weinstein, S. J., & Albanes, D. (2013). Comment on "intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: Pooled results from 5 cohort studies." Annals of Neurology, n/a-n/a. [DOI:10.1002/ana.23952] [PMID] [PMCID]

126. Noh, K.-M., Hwang, J.-Y., Shin, H.-C., & Koh, J.-Y. (2000). A Novel Neuroprotective Mechanism of Riluzole: Direct Inhibition of Protein Kinase C. Neurobiology of Disease, 7(4), 375-383. [DOI:10.1006/nbdi.2000.0297] [PMID]

127. Desnuelle, C., Dib, M., Garrel, C., & Favier, A. (2001). A double-blind, placebo-controlled randomized clinical trial of α-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2(1), 9-18. [DOI:10.1080/146608201300079364] [PMID]

128. Deng, Y., Xu, Z.-F., Liu, W., Xu, B., Yang, H.-B., & Wei, Y.-G. (2012). Riluzole-Triggered GSH Synthesis via Activation of Glutamate Transporters to Antagonize Methylmercury-Induced Oxidative Stress in Rat Cerebral Cortex. Oxidative Medicine and Cellular Longevity, 2012, 534705. [DOI:10.1155/2012/534705] [PMID] [PMCID]

129. Ferroni, P., Barbanti, P., Della-Morte, D., Palmirotta, R., Jirillo, E., & Guadagni, F. (2018). Redox Mechanisms in Migraine: Novel Therapeutics and Dietary Interventions. Antioxidants & Redox Signaling, 28(12), 1144-1183. [DOI:10.1089/ars.2017.7260] [PMID]

130. Baiano, A., & Del Nobile, M. A. (2015). Antioxidant Compounds from Vegetable Matrices: Biosynthesis, Occurrence, and Extraction Systems. Critical Reviews in Food Science and Nutrition, 56(12), 2053-2068. [DOI:10.1080/10408398.2013.812059] [PMID]

131. Chiaiese, P., Corrado, G., Minutolo, M., Barone, A., & Errico, A. (2019). Transcriptional Regulation of Ascorbic Acid During Fruit Ripening in Pepper (Capsicum annuum) Varieties with Low and High Antioxidants Content. Plants, 8(7), 206. [DOI:10.3390/plants8070206] [PMID] [PMCID]

132. Xu, D.-P., Li, Y., Meng, X., Zhou, T., Zhou, Y., Zheng, J., Zhang, J.-J., & Li, H.-B. (2017). Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources. International Journal of Molecular Sciences, 18(1), 96. [DOI:10.3390/ijms18010096] [PMID] [PMCID]

133. Schepetkin, I. A., Ramstead, A. G., Kirpotina, L. N., Voyich, J. M., Jutila, M. A., & Quinn, M. T. (2016). Therapeutic Potential of Polyphenols fromEpilobium Angustifolium(Fireweed). Phytotherapy Research, 30(8), 1287-1297. [DOI:10.1002/ptr.5648] [PMID] [PMCID]

134. D'Onofrio, F., Raimo, S., Spitaleri, D., Casucci, G., & Bussone, G. (2017). Usefulness of nutraceuticals in migraine prophylaxis. Neurological Sciences, 38(S1), 117-120. [DOI:10.1007/s10072-017-2901-1] [PMID]

135. Goschorska, Gutowska, Baranowska-Bosiacka, Barczak, & Chlubek. (2020). The Use of Antioxidants in the Treatment of Migraine. Antioxidants, 9(2), 116. [DOI:10.3390/antiox9020116] [PMID] [PMCID]

136. Shaik, M. M., & Gan, S. H. (2015). Vitamin Supplementation as Possible Prophylactic Treatment against Migraine with Aura and Menstrual Migraine. BioMed Research International, 2015. [DOI:10.1155/2015/469529] [PMID] [PMCID]

137. Kim, M. S., Kim, D. J., Na, C. H., & Shin, B. S. (2016). A Study of Intravenous Administration of Vitamin C in the Treatment of Acute Herpetic Pain and Postherpetic Neuralgia. Annals of Dermatology, 28(6), 677-683. [DOI:10.5021/ad.2016.28.6.677] [PMID] [PMCID]

138. Chayasirisobhon, S. (2006). Use of a Pine Bark Extract and Antioxidant Vitamin Combination Product as Therapy for Migraine in Patients Refractory to Pharmacologic Medication. Headache: The Journal of Head and Face Pain, 46(5), 788-793. [DOI:10.1111/j.1526-4610.2006.00454.x] [PMID]

139. Chayasirisobhon S. (2024). Efficacy of Pinus radiata bark extract and vitamin C combination product as a prophylactic therapy for recalcitrant migraine and long-term results. Acta Neurologica Taiwanica, 22(1).

140. Pulido-Moran, M., Moreno-Fernandez, J., Ramirez-Tortosa, C., & Ramirez-Tortosa, Mc. (2016). Curcumin and Health. Molecules, 21(3), 264. [DOI:10.3390/molecules21030264] [PMID] [PMCID]

141. Bulboacă, A. E., Bolboacă, S. D., Stanescu, I. C., Sfrângeu, C. A., Porfire, A., Tefas, L., & Bulboacă, A. C. (2018). The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats. International Journal of Nanomedicine, Volume 13, 3093-3103. [DOI:10.2147/IJN.S162087] [PMID] [PMCID]

142. Bulboacă, A. E., Bolboacă, S. D., Bulboacă, A. C., Porfire, A. S., Tefas, L. R., Suciu, Ș. M., Dogaru, G., & Stănescu, I. C. (2019). Liposomal Curcumin Enhances the Effect of Naproxen in a Rat Model of Migraine. Medical Science Monitor, 25, 5087-5097. [DOI:10.12659/MSM.915607] [PMID] [PMCID]

143. Abdolahi, M., Tafakhori, A., Togha, M., Okhovat, A. A., Siassi, F., Eshraghian, M. R., Sedighiyan, M., Djalali, M., Mohammadzadeh Honarvar, N., & Djalali, M. (2017). The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients. Immunogenetics, 69(6), 371-378. [DOI:10.1007/s00251-017-0992-8] [PMID]

144. Parohan, M., Sarraf, P., Javanbakht, M. H., Foroushani, A. R., Ranji-Burachaloo, S., & Djalali, M. (2019). The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial. Nutritional Neuroscience, 1-10. [DOI:10.1080/1028415X.2019.1627770] [PMID]

145. Rajapakse, T., & Pringsheim, T. (2016). Nutraceuticals in Migraine: A Summary of Existing Guidelines for Use. Headache: The Journal of Head and Face Pain, 56(4), 808-816. [DOI:10.1111/head.12789] [PMID]

146. Sawaddiruk, P., Apaijai, N., Paiboonworachat, S., Kaewchur, T., Kasitanon, N., Jaiwongkam, T., Kerdphoo, S., Chattipakorn, N., & Chattipakorn, S. C. (2019). Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction. Free Radical Research, 53(8), 901-909. [DOI:10.1080/10715762.2019.1645955] [PMID]

147. Salmon, P. (2001). Effects of physical exercise on anxiety, depression, and sensitivity to stress: A unifying theory. Clinical Psychology Review, 21(1), 33-61. [DOI:10.1016/S0272-7358(99)00032-X] [PMID]

148. Wang, C., Bannuru, R., Ramel, J., Kupelnick, B., Scott, T., & Schmid, C. H. (2010). Tai Chi on psychological well-being: Systematic review and meta-analysis. BMC Complementary and Alternative Medicine, 10(23). [DOI:10.1186/1472-6882-10-23] [PMID]

149. Zaccaro, A., Piarulli, A., Laurino, M., Garbella, E., Menicucci, D., Neri, B., & Gemignani, A. (2018). How breath-control can change your life: A systematic review on psycho-physiological correlates of slow breathing. Frontiers in Human Neuroscience, 12(353). [DOI:10.3389/fnhum.2018.00353] [PMID]

150. Bishop, S. R., Lau, M., Shapiro, S., Carlson, L., Anderson, N. D., Carmody, J., Segal, Z. V., Abbey, S., Speca, M., Velting, D., & Devins, G. (2004). Mindfulness: A proposed operational definition. Clinical Psychology: Science and Practice, 11(3), 230-241. [DOI:10.1093/clipsy.bph077]

151. Fam, J., Sun, Y., Qi, P., Lau, R. C., Feng, L., Kua, E. H., & Mahendran, R. (2020). Mindfulness practice alters brain connectivity in community-living elders with mild cognitive impairment. Psychiatry and Clinical Neurosciences, 74(4), 257-262. [DOI:10.1111/pcn.12972] [PMID]

152. Wu, C., & Feng, Y. (2023). Exploring the potential of mindfulness-based therapy in the prevention and treatment of neurodegenerative diseases based on molecular mechanism studies. Frontiers in Neuroscience, 17, Article 1097067. [DOI:10.3389/fnins.2023.1097067] [PMID] [PMCID]

153. Tang, Y. Y., Hölzel, B. K., & Posner, M. I. (2015). The neuroscience of mindfulness meditation. Nature Reviews Neuroscience, 16(4), 213-225. [DOI:10.1038/nrn3916] [PMID] [PMCID]

154. Goyal, M., Singh, S., Sibinga, E. M., Gould, N. F., Rowland-Seymour, A., Sharma, R., Berger, Z., Sleicher, D., Maron, D. D., Shihab, H. M., Ranasinghe, P. D., Linn, S., Saha, S., Bass, E. B., & Haythornthwaite, J. A. (2014). Meditation programs for psychological stress and well-being: A systematic review and meta-analysis. JAMA Internal Medicine, 174(3), 357-368. [DOI:10.1001/jamainternmed.2013.13018] [PMID]

155. Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., et al. (2020). Dementia prevention, intervention, and care: 2020 report of the lancet commission. The Lancet, 396(10248), 413-446. [DOI:10.1016/S0140-6736(20)30367-6] [PMID]

156. Buric, I., Farias, M., Jong, J., Mee, C., & Brazil, I. A. (2017). What is the molecular signature of mind-body interventions? A systematic review of gene expression changes induced by meditation and related practices. Frontiers in Immunology, 8, 670. [DOI:10.3389/fimmu.2017.00670] [PMID] [PMCID]

157. Boutrup, R. J., Jørgensen, M. M., Gregersen, N., Frost, L., Aagaard, H., Djernis, D., et al. (2019). Psykologiske, neurologiske og cellulære virkningsmekanismer ved mindfulnesstræning, vol. 4

158. Álvarez-López, M. J., Conklin, Q. A., Cosín-Tomás, M., Shields, G. S., King, B. G., & Zanesco, A. P. (2022). Changes in the expression of inflammatory and epigenetic-modulatory genes after an intensive meditation retreat. Comprehensive Psychoneuroendocrinology, 11, 100152. [DOI:10.1016/j.cpnec.2022.100152] [PMID] [PMCID]

159. Bower, J. E., Crosswell, A. D., Stanton, A. L., Crespi, C. M., Winston, D., Arevalo, J., et al. (2015). Mindfulness meditation for younger breast cancer survivors: A randomized controlled trial. Cancer, 121(8), 1231-1240. [DOI:10.1002/cncr.29194] [PMID] [PMCID]

160. Jakaria, M., Haque, M. E., Cho, D.-Y., Azam, S., Kim, I.-S., & Choi, D.-K. (2019). Molecular insights into NR4A2 (Nurr1): An emerging target for neuroprotective therapy against neuroinflammation and neuronal cell death. Molecular Neurobiology, 56(8), 5799-5814. [DOI:10.1007/s12035-019-1487-4] [PMID]

161. Moon, M., Jung, E. S., Jeon, S. G., Cha, M.-Y., Jang, Y., Kim, W., et al. (2019). Nurr1 (NR4A2) regulates Alzheimer's disease-related pathogenesis and cognitive function in the 5XFAD mouse model. Aging Cell, 18(1), e12866. [DOI:10.1111/acel.12866] [PMID] [PMCID]

162. Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018). Hallmarks of cellular senescence. Trends in Cell Biology, 28(6), 436 [DOI:10.1016/j.tcb.2018.02.001] [PMID]

163. Guo, Y., & Yu, H. (2019). Leukocyte telomere length shortening and Alzheimer's disease etiology. Journal of Alzheimer's Disease, 69(4), 881-885. [DOI:10.3233/JAD-190134] [PMID]

164. (Blackburn, E. H., Epel, E. S., & Lin, J. (2015). Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science, 350(6265), 1193-1198. [DOI:10.1126/science.aab3389] [PMID] [PMCID]

165. Epel, E. S., Puterman, E., Lin, J., Blackburn, E. H., Lum, P. Y., Beckmann, N. D., et al. (2016). Meditation and vacation effects have an impact on disease-associated molecular phenotypes. Translational Psychiatry, 6(6), e880. [DOI:10.1038/tp.2016.164] [PMID] [PMCID]

166. Lin, Y., Lu, L., Zhou, M., Liu, H., Ye, P., Zhang, W., et al. (2021). Association of CLU gene polymorphism with Parkinson's disease in the Chinese Han population. Journal of Gene Medicine, 23, e3302. [DOI:10.1002/jgm.3302] [PMID]

167. Maturana-Candelas, A., Gómez, C., Poza, J., Rodríguez-González, V., Pablo, V. G., Lopes, A. M., et al. (2021). Influence of PICALM and CLU risk variants on beta EEG activity in Alzheimer's disease patients. Scientific Reports, 11, 20465. [DOI:10.1038/s41598-021-99589-y] [PMID] [PMCID]

168. Mendioroz, M., Puebla-Guedea, M., Montero-Marín, J., Urdánoz-Casado, A., Blanco-Luquin, I., Roldán, M., et al. (2020). Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners. Scientific Reports, 10, 4564. [DOI:10.1038/s41598-020-61241-6] [PMID] [PMCID]

169. Huang, X.-Y., Eungpinichpong, W., Silsirivanit, A., Nakmareong, S., & Wu, X.-H. (2014). Tai chi improves oxidative stress response and DNA damage/repair in young sedentary females. Journal of Physical Therapy Science, 26(6), 825-829. [DOI:10.1589/jpts.26.825] [PMID] [PMCID]

170. Kumar, A., Singh, A., & Ekavali. (2015). A review on Alzheimer's disease pathophysiology and its management: An update. Pharmacological Reports, 67(2), 195-203. [DOI:10.1016/j.pharep.2014.09.004] [PMID]

171. Wetherell, J. L., Hershey, T., Hickman, S., Tate, S. R., Dixon, D., Bower, E. S., et al. (2017). Mindfulness-based stress reduction for older adults with stress disorders and neurocognitive difficulties: A randomized controlled trial. Journal of Clinical Psychiatry, 78(7), e734-e743. [DOI:10.4088/JCP.16m10947] [PMID]

172. Collin, F. (2019). Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases. International Journal of Molecular Sciences, 20(24), 2407. [DOI:10.3390/ijms20102407] [PMID] [PMCID]

173. Yeung, A. W. K., Tzvetkov, N. T., Georgieva, M. G., Ognyanov, I. V., Kordos, K., & Jóźwik, A. (2021). Reactive oxygen species and their impact in neurodegenerative diseases: Literature landscape analysis. Antioxidants & Redox Signaling, 34(5), 402-420. [DOI:10.1089/ars.2019.7952] [PMID]

174. Hwang, J.-Y., Aromolaran, K. A., & Zukin, R. S. (2017). The emerging field of epigenetics in neurodegeneration and neuroprotection. Nature Reviews Neuroscience, 18(6), 347-361. [DOI:10.1038/nrn.2017.46] [PMID] [PMCID]

175. García-Campayo, J., Puebla-Guedea, M., Labarga, A., Urdánoz, A., Roldán, M., Pulido, L., et al. (2018). Epigenetic response to mindfulness in peripheral blood leukocytes involves genes linked to common human diseases. Mindfulness, 9(4), 1146-1159. [DOI:10.1007/s12671-017-0851-6]

176. Català-Solsona, J., Miñano-Molina, A. J., & Rodríguez-Álvarez, J. (2021). Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review. Frontiers in molecular neuroscience, 14, 786226. [DOI:10.3389/fnmol.2021.786226] [PMID] [PMCID]

177. Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O'Leary, J. C., Fontaine, S. N., et al. (2013). Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. Journal of Clinical Investigation, 123(10), 4158-4169. [DOI:10.1172/JCI69003] [PMID] [PMCID]

178. van der Heide, A., Meinders, M. J., Speckens, A. E. M., Peerbolte, T. F., Bloem, B. R., & Helmich, R. C. (2021). Stress and mindfulness in Parkinson's disease: Clinical effects and potential underlying mechanisms. Movement Disorders, 36(1), 64-70. [DOI:10.1002/mds.28345] [PMID] [PMCID]

179. Ratti, A., Gumina, V., Lenzi, P., Bossolasco, P., Fulceri, F., & Volpe, C. (2020). Chronic stress induces formation of stress granules and pathological TDP-43 aggregates in human ALS fibroblasts and iPSC-motoneurons. Neurobiology of Disease, 145, 105051. [DOI:10.1016/j.nbd.2020.105051] [PMID]

180. Frodl, T., & O'Keane, V. (2013). How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function, and hippocampal structure in humans. Neurobiology of Disease, 52, 24-37. [DOI:10.1016/j.nbd.2012.03.012] [PMID]

181. Brureau, A., Zussy, C., Delair, B., Ogier, C., Ixart, G., Maurice, T., et al. (2013). Deregulation of hypothalamic-pituitary-adrenal axis functions in an Alzheimer's disease rat model. Neurobiology of Aging, 34(6), 1426-1439. [DOI:10.1016/j.neurobiolaging.2012.11.015] [PMID]

182. Vyas, S., & Maatouk, L. (2013). Contribution of glucocorticoids and glucocorticoid receptors to the regulation of neurodegenerative processes. CNS & Neurological Disorders - Drug Targets, 12(9), 1175-1193. [DOI:10.2174/187152731131200125]

183. Notarianni, E. (2013). Hypercortisolemia and glucocorticoid receptor-signaling insufficiency in Alzheimer's disease initiation and development. Current Alzheimer Research, 10(7), 714-731. [DOI:10.2174/15672050113109990137] [PMID]

184. Milligan Armstrong, A., Porter, T., Quek, H., White, A., Haynes, J., & Jackaman, C. (2021). Chronic stress and Alzheimer's disease: The interplay between the hypothalamic-pituitary-adrenal axis, genetics, and microglia. Biological Reviews, 96(4), 2209-2228. [DOI:10.1111/brv.12750] [PMID]

185. Khalsa, D. S. (2015). Stress, meditation, and Alzheimer's disease prevention: Where the evidence stands. Journal of Alzheimer's Disease, 48(1), 1-12. [DOI:10.3233/JAD-142766] [PMID]

186. Athanasiou, N., Bogdanis, G. C., & Mastorakos, G. (2023). Endocrine responses of the stress system to different types of exercise. Reviews in Endocrine and Metabolic Disorders, 24, 251-266. [DOI:10.1007/s11154-022-09758-1] [PMID] [PMCID]

187. Heijnen, S., Hommel, B., Kibele, A., & Colzato, L. S. (2016). Neuromodulation of aerobic exercise-A review. Frontiers in Psychology, 6, 1890. [DOI:10.3389/fpsyg.2015.01890] [PMID] [PMCID]

188. Jefri, M., Bell, S., Peng, H., Hettige, N., Maussion, G., Soubannier, V., Wu, H., Silveira, H., Theroux, J. F., Moquin, L., Zhang, X., Aouabed, Z., Krishnan, J., O'Leary, L. A., Antonyan, L., Zhang, Y., McCarty, V., Mechawar, N., Gratton, A., Schuppert, A., … Ernst, C. (2020). Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells. Stem cells translational medicine, 9(6), 697-712. [DOI:10.1002/sctm.18-0180] [PMID] [PMCID]

189. Tillage, R. P., Wilson, G. E., Liles, L. C., Holmes, P. V., & Weinshenker, D. (2020). Chronic Environmental or Genetic Elevation of Galanin in Noradrenergic Neurons Confers Stress Resilience in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(39), 7464-7474. [DOI:10.1523/JNEUROSCI.0973-20.2020] [PMID] [PMCID]

190. Zimmer, P., Stritt, C., Bloch, W., et al. (2016). The effects of different aerobic exercise intensities on serum serotonin concentrations and their association with Stroop task performance: A randomized controlled trial. European Journal of Applied Physiology, 116(11-12), 2025-2034. [DOI:10.1007/s00421-016-3456-1] [PMID]

191. Lin, T. W., Shih, Y. H., Chen, S. J., Lien, C. H., Chang, C. Y., Huang, T. Y., Chen, S. H., Jen, C. J., & Kuo, Y. M. (2015). Running exercise delays neurodegeneration in the amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice. Neurobiology of Learning and Memory, 118, 189-197. [DOI:10.1016/j.nlm.2014.12.005] [PMID]

192. von Bohlen Und Halbach, O., & von Bohlen Und Halbach, V. (2018). BDNF effects on dendritic spine morphology and hippocampal function. Cell and Tissue Research, 373(3), 729-741. [DOI:10.1007/s00441-017-2782-x] [PMID]

193. Fahimi, A., Baktir, M. A., Moghadam, S., Mojabi, F. S., Sumanth, K., McNerney, M. W., Ponnusamy, R., & Salehi, A. (2017). Physical exercise induces structural alterations in the hippocampal astrocytes: Exploring the role of BDNF-TrkB signaling. Brain Structure and Function, 222(4), 1797-1808. [DOI:10.1007/s00429-016-1308-8] [PMID]

194. Zsuga, J., Tajti, G., Papp, C., Juhasz, B., & Gesztelyi, R. (2016). FNDC5/irisin: A molecular target for boosting reward-related learning and motivation. Medical Hypotheses, 90, 23-28. [DOI:10.1016/j.mehy.2016.02.020] [PMID]

195. Park, H. S., Park, S. S., Kim, C. J., Shin, M. S., & Kim, T. W. (2019). Exercise alleviates cognitive functions by enhancing hippocampal insulin signaling and neuroplasticity in high-fat diet-induced obesity. Nutrients, 11(7), 1603. [DOI:10.3390/nu11071603] [PMID] [PMCID]

196. Dodd, G. T., & Tiganis, T. (2017). Insulin action in the brain: Roles in energy and glucose homeostasis. Journal of Neuroendocrinology, 29, e12513. [DOI:10.1111/jne.12513] [PMID]

197. Rege, S. D., et al. (2018). Neuroprotective effects of resveratrol: Role of PI3K/Akt and ERK signaling pathways. Neurobiology of Aging, 66, 69-79.

198. Lockshin, E. R., & Calakos, N. (2024). The integrated stress response in brain diseases: A double-edged sword for proteostasis and synapses. Current opinion in neurobiology, 87, 102886. [DOI:10.1016/j.conb.2024.102886] [PMID] [PMCID]

199. Pakos-Zebrucka, K., et al. (2016). The integrated stress response. EMBO Reports, 17(10), 1374-1395. [DOI:10.15252/embr.201642195] [PMID]

200. Hicks, D., Giresh, K., Wrischnik, L. A., & Weiser, D. C. (2023). The PPP1R15 family of eIF2-alpha phosphatase targeting subunits (GADD34 and CReP). International Journal of Molecular Sciences, 24(17), 17321. [DOI:10.3390/ijms242417321] [PMID] [PMCID]

201. Jiménez-Díaz, A., Remacha, M., Ballesta, J. P., & Berlanga, J. J. (2013). Phosphorylation of initiation factor eIF2 in response to stress conditions is mediated by acidic ribosomal P1/P2 proteins in Saccharomyces cerevisiae. PloS one, 8(12), e84219. [DOI:10.1371/journal.pone.0084219] [PMID] [PMCID]

202. Giridharan, S., & Srinivasan, M. (2018). Mechanisms of NF-κB p65 and strategies for therapeutic manipulation. Journal of Inflammation Research, 11, 407-419. [DOI:10.2147/JIR.S140188] [PMID]

203. Corti, O., Blomgren, K., Poletti, A., & Beart, P. M. (2020). Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases. Journal of Neurochemistry, 154(4), 354-371. [DOI:10.1111/jnc.15002] [PMID]

204. Aber, E. R., Griffey, C. J., Davies, T., Li, A. M., Yang, Y. J., Croce, K. R., Goldman, J. E., Grutzendler, J., Canman, J. C., & Yamamoto, A. (2022). Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death. Cell Reports, 41(3), 111480. [DOI:10.1016/j.celrep.2022.111480] [PMID] [PMCID]

205. Yi, J., & Luo, J. (2010). SIRT1 and p53, effect on cancer, senescence and beyond. Biochimica et biophysica acta, 1804(8), 1684-1689. [DOI:10.1016/j.bbapap.2010.05.002] [PMID] [PMCID]

206. Qazi, T. J., Lu, J., Duru, L., Zhao, J., & Qing, H. (2021). Upregulation of miR-132 induces dopaminergic neuronal death via activating SIRT1/P53 pathway. Neuroscience Letters, 740, 135465. [DOI:10.1016/j.neulet.2020.135465] [PMID]

207. Bathina, S., & Das, U. N. (2015). Brain-derived neurotrophic factor and its clinical implications. Archives of Medical Science, 11(6), 1164-1178. [DOI:10.5114/aoms.2015.56342] [PMID] [PMCID]

208. Jeong, H., Cohen, D. E., Cui, L., et al. (2011). Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nature Medicine, 18(1), 159-165. [DOI:10.1038/nm.2559] [PMID] [PMCID]

209. Gomes, B. A., Silva, J. P., Romeiro, C. F., et al. (2018). Neuroprotective mechanisms of resveratrol in Alzheimer's disease: Role of SIRT1. Oxidative Medicine and Cellular Longevity, 2018, 8152373. [DOI:10.1155/2018/8152373] [PMID] [PMCID]

210. Paul, B. D., Snyder, S. H., & Bohr, V. A. (2021). Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging. Trends in neurosciences, 44(2), 83-96. [DOI:10.1016/j.tins.2020.10.008] [PMID] [PMCID]

211. Motwani, M., Pesiridis, S., & Fitzgerald, K. A. (2019). DNA sensing by the cGAS-STING pathway in health and disease. Nature Reviews Genetics, 20(11), 657-674. [DOI:10.1038/s41576-019-0151-1] [PMID] [PMCID]

212. Chin, A. C. (2019). Neuroinflammation and the cGAS-STING pathway. Journal of Neurophysiology, 121(4), 1087-1091. [DOI:10.1152/jn.00848.2018] [PMID]

213. Li, Q., et al. (2021). Therapeutic development by targeting the cGAS-STING pathway in autoimmune disease and cancer. Frontiers in Pharmacology, 12, 779425. [DOI:10.3389/fphar.2021.779425] [PMID] [PMCID]

214. Tian, X., et al. (2022). Medicinal chemistry perspective on cGAS-STING signaling pathway with small molecule inhibitors. European Journal of Medicinal Chemistry, 244, 114791. [DOI:10.1016/j.ejmech.2022.114791] [PMID]

215. Chu, L., et al. (2021). Perillaldehyde inhibition of cGAS reduces dsDNA-induced interferon response. Frontiers in Immunology, 12, 655637. [DOI:10.3389/fimmu.2021.655637] [PMID] [PMCID]

216. Valentin, R., et al. (2021). Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2′-O-methyl gapmer oligonucleotides. Nucleic Acids Research, 49(11), 6082-6099. [DOI:10.1093/nar/gkab451] [PMID] [PMCID]

217. Ding, C., et al. (2020). Small molecules targeting the innate immune cGAS-STING-TBK1 signaling pathway. Acta Pharmaceutica Sinica B, 10(12), 2272-2298. [DOI:10.1016/j.apsb.2020.03.001] [PMID] [PMCID]

218. Vincent, J., et al. (2017). Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nature Communications, 8(1), 750. [DOI:10.1038/s41467-017-00833-9] [PMID]

219. Hall, J., et al. (2017). Discovery of PF-06928215 as a high-affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE, 12(9), e0184843. [DOI:10.1371/journal.pone.0184843] [PMID] [PMCID]

220. Lama, L., et al. (2019). Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nature Communications, 10(1), 2261. [DOI:10.1038/s41467-019-08620-4] [PMID] [PMCID]

221. An, J., et al. (2017). Antimalarial drugs as immune modulators: New mechanisms for old drugs. Annual Review of Medicine, 68, 317-330. [DOI:10.1146/annurev-med-043015-123453] [PMID]

222. Wang, M., et al. (2018). Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels. Future Medicinal Chemistry, 10(11), 1301-1317. [DOI:10.4155/fmc-2017-0322] [PMID]

223. Padilla-Salinas, R., et al. (2020). Discovery of small-molecule cyclic GMP-AMP synthase inhibitors. Journal of Organic Chemistry, 85(3), 1579-1600. [DOI:10.1021/acs.joc.9b02666] [PMID]

224. Liu, Z. S., et al. (2019). G3BP1 promotes DNA binding and activation of cGAS. Nature Immunology, 20(1), 18-28. [DOI:10.1038/s41590-018-0262-4] [PMID] [PMCID]

225. Dai, J., et al. (2019). Acetylation blocks cGAS activity and inhibits self-DNA-induced autoimmunity. Cell, 176(6), 1447-1460.e14. [DOI:10.1016/j.cell.2019.01.016] [PMID] [PMCID]

226. Huang, Y., Liu, B., Sinha, S. C., Amin, S., & Gan, L. (2023). Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders. Molecular neurodegeneration, 18(1), 79. [DOI:10.1186/s13024-023-00672-x] [PMID] [PMCID]