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Haghipanah M, Saadat M, Safarbalou A, Budde T, Mohamed W, Sadat Afraz E et al . The effects of oral supplementation of Japanese sake yeast on anxiety, depressive-like symptoms, oxidative stress, and BDNF changes in chronically stressed adolescent rats. Neuroscience Updates 2023; 1 (1) :1-8
URL: http://neuroupdates.de/article-1-90-en.html
The effects of oral supplementation of Japanese sake yeast on anxiety, depressive-like symptoms, oxidative stress, and BDNF changes in chronically stressed adolescent rats
Motahareh Haghipanah1 , Maryam Saadat2 , Asal Safarbalou1 , Thomas Budde3 , Wael Mohamed4 , Elham Sadat Afraz *5 , Nasrollah Moradikor1
1- International Center for Neuroscience Research, Institute for Intelligent Research, Tbilisi, Georgia
2- Department of Anatomical Sciences, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
3- Institut für Physiologie I, Westfälische Wilhelms-Universität, Münster, Germany
4- Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Pahang, Malaysia
5- Department of Oral Medicine, School of Dentistry, Semnan University of Medical Sciences, Semnan, Iran
Abstract:   (7508 Views)

Chronic stress during the pre-pubertal period has adverse effects in developing neuropsychiatric disorders such as depression and anxiety. The administration of supplements with antioxidant properties may alleviate depression and anxiety behavior. This study investigated the effects of oral supplementation of Japanese sake yeast on anxiety, depressive-like symptoms, oxidative stress, and changes in brain-derived neurotropic factor (BDNF) in adolescence rats subjected to chronic stress. In order to assess the effects of chronic stress, adolescent rats were grouped into one non-stressed control group (non-stress) and four different experimental groups. The other animals were subjected to stress and orally received normal saline (Control-stress), 15 mg/kg yeast (Stress-15), 30 mg/kg yeast (Stress-30) and 45 mg/kg yeast (Stress-45). Anxiety and depression-like behavior, BDNF levels, and oxidative stress markers were evaluated. The rats exposed to stress exhibited anxiogenic and depression-like behavior as well as lower levels of BDNF and higher levels of oxidative markers compared with non-stressed rats (P<0.05). However, the oral supplementation of sake yeast decreased anxiogenic and depression-like behavior and oxidative indices, and also increased BDNF levels compared to stressed rats treated with saline in a dose-dependent manner (P<0.05). In sum, stress caused anxiety and depression behavior, increased oxidative indices, and reduced BDNF levels while sake yeast alleviated adverse effects of stress on anxiety and depression behaviors, decreased oxidative markers, and increased BDNF levels. 

Keywords: Anxiety, BDNF, Depression, Oxidative markers, Rat model, Sake yeast
Full-Text [PDF 832 kb]   (2534 Downloads)    
Type of Study: Original Article | Subject: Behavioral Neuroscience
Received: 2022/11/18 | Accepted: 2023/02/25 | Published: 2023/04/15
References
1. Moradi-Kor, N.; Dadkhah, M.; Ghanbari, A.; Rashidipour, H.; Bandegi, A. R.; Barati, M., et al., Protective effects of spirulina platensis, voluntary exercise and environmental interventions against adolescent stress-induced anxiety and depressive-like symptoms, oxidative stress and alterations of BDNF and 5HT-3 receptors of the prefrontal cortex in female rats. Neuropsychiatric Disease and Treatment 2020, 16, 1777. [DOI:10.2147/ndt.s247599] [PMID] [PMCID]
2. Dow-Edwards, D.; MacMaster, F. P.; Peterson, B. S.; Niesink, R.; Andersen, S.; Braams, B., Experience during adolescence shapes brain development: From synapses and networks to normal and pathological behavior. Neurotoxicology and Teratology 2019, 76, 106834. [DOI:10.1016/j.ntt.2019.106834] [PMID]
3. Feiss, R.; Dolinger, S. B.; Merritt, M.; Reiche, E.; Martin, K.; Yanes, J. A.; et al., A systematic review and meta-analysis of school-based stress, anxiety, and depression prevention programs for adolescents. Journal of Youth and Adolescence 2019, 48 (9), 1668-1685. [DOI:10.1007/s10964-019-01085-0] [PMID] [PMCID]
4. Yahfoufi, N.; Matar, C.; Ismail, N., Adolescence and aging: Impact of adolescence inflammatory stress and microbiota alterations on brain development, aging, and neurodegeneration. The Journals of Gerontology: Series A 2020, 75 (7), 1251-1257. [DOI:10.1093/gerona/glaa006] [PMID] [PMCID]
5. McEwen, B. S.; Nasca, C.; Gray, J. D., Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex. Neuropsychopharmacology 2016, 41 (1), 3-23. [DOI:10.1038/npp.2015.171] [PMID] [PMCID]
6. Bale, T. L.; Baram, T. Z.; Brown, A. S.; Goldstein, J. M.; Insel, T. R.; McCarthy, M. M.; et al., Early life programming and neurodevelopmental disorders. Biological Psychiatry 2010, 68 (4), 314-319. [DOI:10.1016/j.biopsych.2010.05.028] [PMID] [PMCID]
7. Brown, G. W.; Ban, M.; Craig, T. K.; Harris, T. O.; Herbert, J.; Uher, R., Serotonin transporter length polymorphism, childhood maltreatment, and chronic depression: a specific gene-environment interaction. Depression and Anxiety 2013, 30 (1), 5-13. [DOI:10.1002/da.21982] [PMID]
8. Brydges, N. M.; Jin, R.; Seckl, J.; Holmes, M. C.; Drake, A. J.; Hall, J., Juvenile stress enhances anxiety and alters corticosteroid receptor expression in adulthood. Brain and Behavior 2014, 4 (1), 4-13. [DOI:10.1002/brb3.182] [PMID] [PMCID]
9. Wang, Y-L.; Han, Q-Q.; Gong, W-Q.; Pan, D-H.; Wang, L-Z.; Hu, W.; et al., Microglial activation mediates chronic mild stress-induced depressive-and anxiety-like behavior in adult rats. Journal of Neuroinflammation 2018, 15 (1), 1-14. [DOI:10.1186/s12974-018-1054-3] [PMID] [PMCID]
10. Di Liberto, V.; Frinchi, M.; Verdi, V.; Vitale, A.; Plescia, F.; Cannizzaro, C.; et al., Anxiolytic effects of muscarinic acetylcholine receptors agonist oxotremorine in chronically stressed rats and related changes in BDNF and FGF2 levels in the hippocampus and prefrontal cortex. Psychopharmacology 2017, 234 (4), 559-573. [DOI:10.1007/s00213-016-4498-0] [PMID]
11. Floyd, R. A., Antioxidants, oxidative stress, and degenerative neurological disorders. Proceedings of the Society for Experimental Biology and Medicine. 1999, 222 (3), 236-245. [DOI:10.1046/j.1525-1373.1999.d01-140.x] [PMID]
12. Singh, R. P.; Sharad, S.; Kapur, S., Free radicals and oxidative stress in neurodegenerative diseases: relevance of dietary antioxidants. Journal, Indian Academy of Clinical Medicine 2004, 5 (3), 218-225.
13. Popović, N.; Stojiljković, V.; Pejić, S.; Todorović, A.; Pavlović, I.; Gavrilović, L.; et al., Modulation of hippocampal antioxidant defense system in chronically stressed rats by lithium. Oxidative Medicine and Cellular Longevity 2019. [DOI:10.1155/2019/8745376] [PMID] [PMCID]
14. Masood, A.; Nadeem, A.; Mustafa, S. J.; O'Donnell, J. M., Reversal of oxidative stress-induced anxiety by inhibition of phosphodiesterase-2 in mice. Journal of Pharmacology and Experimental Therapeutics 2008, 326 (2), 369-379. [DOI:10.1124/jpet.108.137208] [PMID] [PMCID]
15. Nakahara, M.; Mishima, T.; Hayakawa, T., Effect of a sake concentrate on the epidermis of aged mice and confirmation of ethyl α-D-glucoside as its active component. Bioscience, Biotechnology, and Biochemistry 2007, 71 (2), 427-434. [DOI:10.1271/bbb.60489] [PMID]
16. Davoodi, M.; Karimooy, F. N.; Budde, T.; Ortega-Martinez, S.; Moradi-Kor, N., Beneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019, 12, 1667. [DOI:10.2147/dmso.s220181] [PMID] [PMCID]
17. Zhang, K.; Wu, W.; Yan, Q., Research advances on sake rice, koji, and sake yeast: A review. Food Science & Nutrition 2020, 8 (7), 2995-3003. [DOI:10.1002/fsn3.1625] [PMID] [PMCID]
18. Moradi-Kor, N.; Ghanbari, A.; Rashidipour, H.; Yousefi, B.; Bandegi, A. R.; Rashidy-Pour, A., Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats. Hormones and Behavior 2019, 112, 20-31. [DOI:10.1016/j.yhbeh.2019.03.004] [PMID]
19. Vyas, A.; Mitra, R.; Rao, B. S.; Chattarji, S., Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. Journal of Neuroscience 2002, 22 (15), 6810-6818. [DOI:10.1523/JNEUROSCI.22-15-06810.2002] [PMID] [PMCID]
20. Borsini, F.; Meli, A., Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology 1988, 94 (2), 147-160. [DOI:10.1007/bf00176837] [PMID]
21. Ilin, Y.; Richter-Levin, G., Enriched environment experience overcomes learning deficits and depressive-like behavior induced by juvenile stress. PLoS One 2009, 4 (1), e4329. [DOI:10.1371/journal.pone.0004329] [PMID] [PMCID]
22. Eiland, L.; Ramroop, J.; Hill, M. N.; Manley, J.; McEwen, B. S., Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats. Psychoneuroendocrinology 2012, 37 (1), 39-47. [DOI:10.1016/j.psyneuen.2011.04.015] [PMID] [PMCID]
23. Duman, R. S.; Monteggia, L. M., A neurotrophic model for stress-related mood disorders. Biological Psychiatry 2006, 59 (12), 1116-1127. [DOI:10.1016/j.biopsych.2006.02.013] [PMID] [PMCID]
24. Hoshaw, B. A.; Malberg, J. E.; Lucki, I., Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects. Brain Research 2005, 1037 (1-2), 204-208. [DOI:10.1016/j.brainres.2005.01.007] [PMID]
25. Roth, T. L.; Lubin, F. D.; Funk, A. J.; Sweatt, J. D., Lasting epigenetic influence of early-life adversity on the BDNF gene. Biological Psychiatry 2009, 65 (9), 760-769. [DOI:10.1016/j.biopsych.2008.11.028] [PMID] [PMCID]
26. Bai, M.; Zhu, X.; Zhang, Y.; Zhang, S.; Zhang, L.; Xue, L.; et al., Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life. 2012. [DOI:10.1371/journal.pone.0046921] [PMID]
27. Metodiewa, D.; Kośka, C., Reactive oxygen species and reactive nitrogen species: relevance to cyto (neuro) toxic events and neurologic disorders. An overview. Neurotoxicity Research 1999, 1 (3), 197-233. [DOI:10.1007/bf03033290] [PMID]
28. McIntosh, L. J.; Hong, K. E.; Sapolsky, R. M., Glucocorticoids may alter antioxidant enzyme capacity in the brain: baseline studies. Brain Research 1998, 791 (1-2), 209-214. [DOI:10.1016/s0006-8993(98)00115-2] [PMID]
29. Liu, J.; Wang, X.; Shigenaga, M. K.; Yeo, H. C.; Mori, A.; Ames, B. N., Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats. The FASEB Journal 1996, 10 (13), 1532-1538. [DOI:10.1096/fasebj.10.13.8940299] [PMID]
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