Volume 2, Issue 1 (1-2024)                   Neuroscience Updates 2024, 2(1): 67-98 | Back to browse issues page

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Abdallnasser Amen R, Atef Essmat R, Mohamed Atallah E. Breaking Down Under Stress: Exploring the Impact of Stress on the Brain and Neurodegenerative Disorders. Neuroscience Updates 2024; 2 (1) :67-98
URL: http://neuroupdates.de/article-1-114-en.html
Breaking Down Under Stress: Exploring the Impact of Stress on the Brain and Neurodegenerative Disorders
Radwa Abdallnasser Amen1 , Rawan Atef Essmat2 , Esraa Mohamed Atallah *3
1- Department of Biotechnology, Faculty of Science, Cairo University, Egypt
2- Faculty of Pharmacy, Modern University for Information and Technology, Egypt
3- Department of Zoology, Faculty of Science, Mansoura University, Egypt
Abstract:   (2258 Views)
This review shows challenges neurological pathologies of various disorders inducing migraine, amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's diseases caused by stress. Long-lasting stress triggers a series of biochemical reactions that cause the degeneration of neurons and causing long-lasting cognitive impairment. The most cause of neurological disorders are oxidative stress, neuroinflammation, and mitochondrial dysfunction. In the case of Alzheimer's disease, stress can exacerbate Alzheimer's pathology by enhancing tau protein to be phosphorylated and triggering the misfolding of amyloid-beta protein. Stress in Parkinson’s disease is a leading factor in alpha-synuclein aggregation and the subsequent death of dopaminergic neurons. A variety of therapeutic strategies aimed at mitigating these stress-related pathways are under investigation as anti-inflammatory strategies, antioxidant therapies, and agents supporting mitochondrial function. The review outlines neuroprotective effects of lifestyle interventions: cognitive behavioral therapy, regular physical exercise, and diet-related approaches. current research underlines the need for comprehensive therapeutic approaches targeting stress-related mechanisms in attempts to delay the causes of neurodegenerative diseases and improve patient health.
Keywords: Oxidative stress, Chronic stress, Brain inflammation, Mitochondrial dysfunction, Neurodegenerative disorders
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Type of Study: Review Article | Subject: Neurodegenerative Disease
Received: 2024/09/5 | Accepted: 2024/11/20 | Published: 2024/12/10
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