Volume 2, Issue 1 (1-2024)                   Neuroscience Updates 2024, 2(1): 108-121 | Back to browse issues page

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Soliman Wadan A, El-Gemaie D S, Abdelsattar Ahmed M. Emerging Insights into Gut-Brain Axis Dysregulation in Neurodegenerative Disorders. Neuroscience Updates 2024; 2 (1) :108-121
URL: http://neuroupdates.de/article-1-116-en.html
Emerging Insights into Gut-Brain Axis Dysregulation in Neurodegenerative Disorders
Al-Hassan Soliman Wadan *1 , Dana Saeed El-Gemaie2 , Mohamed Abdelsattar Ahmed3
1- Department of Oral Biology, Faculty of Dentistry, Galala University, Suez, Egypt
2- Department of Endodontics, Faculty of Dentistry, Galala University, Suez, Egypt
3- Faculty of Dentistry, Sinai University, Kantara Branch, Ismailia, Egypt
Abstract:   (1792 Views)
This review explores the emerging insights into the gut-brain axis (GBA) and its dysregulation in neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's. The GBA represents a complex communication network linking the intestinal microbiome with the central nervous system (CNS), facilitated by neuro-immuno-endocrine mediators. Such interactions profoundly influence brain health, cognitive functions, and various systemic diseases. Dysbiosis of gut microbiota may be implicated in the pathogenesis of neurodegenerative conditions through mechanisms involving inflammation, metabolic regulation, and neurotransmitter activity. Additionally, dietary habits, lifestyle choices, and environmental factors significantly affect individual gut microbiota profiles, further shaping neurological health. The review highlights the potential of microbiome-based therapies as innovative intervention strategies, emphasizing the metabolic contribution of gut bacteria, such as short-chain fatty acids (SCFAs), to brain function and mood regulation. Understanding these intricate relationships paves the way for novel therapeutic targets to ameliorate neurodegenerative symptoms and enhance overall brain health.
 
Keywords: Gut-Brain Axis, Alzheimer's, Huntington's, Parkinson's
Full-Text [PDF 1185 kb]   (670 Downloads)    
Type of Study: Review Article | Subject: Neurodegenerative Disease
Received: 2024/10/20 | Accepted: 2024/12/5 | Published: 2024/12/15
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