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Neuroscience Updates 2024, 2(1): 46-52 |
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Shaidy N, Haszlihisham H, Haider F, Shaharudin N, Jalil N, Mohamed W. Neuroprotective Effects of Edible Bird Nest Towards Parkinson’s Disease. Neuroscience Updates 2024; 2 (1) :46-52
URL: http://neuroupdates.de/article-1-111-en.html
URL: http://neuroupdates.de/article-1-111-en.html
Noor Shaidy1 
, Husna Haszlihisham1 , Fatimah Haider1 , Nursyafiqah Shaharudin2 , Nur Jalil2 , Wael Mohamed *3 
, Husna Haszlihisham1 , Fatimah Haider1 , Nursyafiqah Shaharudin2 , Nur Jalil2 , Wael Mohamed *3
1- Department of Chemistry, Kulliyyah of Science, International Islamic University Malaysia (IIUM), Pahang, Malaysia
2- Department of Nutrition Sciences, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia (IIUM), Pahang, Malaysia
3- Department of Basic Medical Science, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Pahang, Malaysia
2- Department of Nutrition Sciences, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia (IIUM), Pahang, Malaysia
3- Department of Basic Medical Science, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Pahang, Malaysia
Abstract: (8278 Views)
Parkinson’s Disease (PD), is closely related to the neurological disorder due to the degeneration of dopaminergic neurons caused by oxidative stress and nitrosative. Over the years, studies regarding the treatment for PD are continuously done as there is still no permanent cure for PD. Edible bird’s nests, EBN are known for their neuroprotective effect which are used as the potential treatment for PD. This article aims to highlight the association of EBN and PD. EBN has the potential to inhibit the degeneration of the dopaminergic neurons against 6-OHDA, which causes the production of nitric oxide and lipid peroxidation in SH-SY5Y cells. The bioactive ingredients that are responsible for the neuroprotective effect of EBN, such as lactoferrin, ovotransferrin, melatonin, sialic acid and epidermal growth factor (EGF) are discussed. Moreover, suitable dosage forms of the EBN are required to serve the patients’ needs as well as to deliver the content of EBN efficiently to the target. Hence, the dosage forms of EBN that are available in the market nowadays are addressed. The effects and mechanism of EBN as an antioxidant and anti-apoptosis to treat PD are further elaborated. The concern regarding the toxicology of EBN is highlighted due the content of heavy metals such as arsenic, mercury, lead, cadmium, and tin in raw EBN that needs to be considered. This is because the accumulation of heavy metals in the body can lead to several health issues. The understanding and research between the background of PD and the promising effect of EBN may lead to the discovery of drugs for PD.
Keywords: Parkinson’s disease (PD), Edible bird’s nest (EBN), 6-OHDA, Lactoferrin, Ovotransferrin, Melatonin
Type of Study: Review Article |
Subject:
Neurodegenerative Disease
Received: 2023/12/20 | Accepted: 2024/05/15 | Published: 2024/08/30
Received: 2023/12/20 | Accepted: 2024/05/15 | Published: 2024/08/30
References
1. NIH National Institute on Aging (NIA)., Parkinson's disease: causes, symptoms, and treatments 2022.
2. Yew, M. Y.; Koh, R. Y.; Chye, S. M.; Othman, I.; Soga, T.; Parhar, I.; Ng, K. Y., Edible bird's nest improves motor behavior and protects dopaminergic neurons against oxidative and nitrosative stress in Parkinson's disease mouse model. Journal of Functional Foods 2018, 48, 576-585. [DOI:10.1016/j.jff.2018.07.058]
3. World Health Organization (WHO)., Parkinson disease 2022.
4. Lee, T. H.; Wani, W. A.; Lee, C. H.; Cheng, K. K.; Shreaz, S.; Wong, S.; Hamdan, N.; Azmi, N. A., Edible bird's nest: The functional values of the prized animal-based bioproduct from southeast asia-A review. Frontiers in Pharmacology 2021, 12. [DOI:10.3389/fphar.2021.626233] [PMID] [PMCID]
5. Chu, W.; Phan, C. W.; Lim, S. J.; Babji, A. S., Insights on the molecular mechanism of neuroprotection exerted by edible bird's nest and its bioactive constituents. Food Science and Human Wellness 2023, 12(4), 1008-1019. [DOI:10.1016/j.fshw.2022.10.021]
6. Loh, S.-P.; Cheng, S.-H.; Mohamed, W., Edible bird's nest as a potential cognitive enhancer. Frontiers in Neurology 2022, 13. [DOI:10.3389/fneur.2022.865671] [PMID] [PMCID]
7. Yew, M. Y., Investigation of neuroprotective and neurotrophic effects of edible bird's nest in parkinson's disease models (Version 1) 2019.
8. Tan, H. Y.; Babji, A. S.; Lim, S. J.; Sarbini, S. R., A systematic review of edible Swiftlet's nest (ESN): Nutritional bioactive compounds, health benefits as functional food, and recent development as bioactive ESN glycopeptide hydrolysate. Trends in Food Science & Technology 2021.
9. Chok, K. C.; Ng, M. G.; Ng, K. Y.; Koh, R. Y.; Tiong, Y. L.; Chye, S. M., Edible bird's nest: Recent updates and industry insights based on laboratory findings. Frontiers in Pharmacology 2021, 12. [DOI:10.3389/fphar.2021.746656] [PMID] [PMCID]
10. Acharya, C.; Satheesh, N. Edible bird's nest (EBN): Production, processing, food and medicinal importance 2023, 4, 20-25.
11. Yew, M.; Koh, R.; Chye, S.; Othman, I.; Ng, K., Edible bird's nest ameliorates oxidative stress-induced apoptosis in SH-SY5Y human neuroblastoma cells. BMC Complementary and Alternative Medicine 2014, 14(1). [DOI:10.1186/1472-6882-14-391] [PMID] [PMCID]
12. Henrich, M.T.; Oertel, W.H.; Surmeier, D.J., et al., Mitochondrial dysfunction in Parkinson's disease - A key disease hallmark with therapeutic potential. Molecular Neurodegeneration 2023, 18(83). [DOI:10.1186/s13024-023-00676-7] [PMID] [PMCID]
13. Rashed, A. A.; Ahmad, H.; Khalid, S. K. A.; Rathi D-N. G.; The potential use of sialic acid from edible bird's nest to attenuate mitochondrial dysfunction by in vitro study. Frontiers in Pharmacology 2021, 12(633303). [DOI:10.3389/fphar.2021.633303] [PMID] [PMCID]
14. Bellinger, F.; Bellinger, M.; Seale, L, et al., Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain. Molecular Neurodegeneration 2011, 6(1). [DOI:10.1186/1750-1326-6-8] [PMID] [PMCID]
15. Power, J.; Blumbergs, P., Cellular glutathione peroxidase in human brain: Cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Acta Neuropathologica 2009, 117(1); 63-73. [DOI:10.1007/s00401-008-0438-3] [PMID]
16. Dheen, S.; Kaur, C.; Ling, E.; Microglial activation and its implications in the brain diseases. Current medicinal chemistry 2007, 14(11): 1189-1197. [DOI:10.2174/092986707780597961] [PMID]
17. Erekat, N. S., Apoptosis and its role in Parkinson's disease. In: Stoker TB, Greenland JC, editors. Parkinson's Disease: Pathogenesis and Clinical Aspects 2018.
18. Tan, S.; Shobana, C.; Sani, Lim, C.; Ideris, A.; Stanslas, J.; Lim, T. Safety profile and nutritional content of raw cleaned edible bird's nest.
19. Jaishankar, M.; Tseten, T.; Anbalagan, N.; Mathew, B. B.; Beeregowda, K. N.; Toxicity, mechanism and health effects of some heavy metals. Interdisciplinary toxicology 2014, 7(2), 60. [DOI:10.2478/intox-2014-0009] [PMID]
20. An investigation of heavy metals in edible bird's nest from Indonesia using inductively coupled plasma mass spectrometry.
21. Chen, J. X. J.; Lim, P. K. C.; Wong, S. F.; Mak, J. W., Determination of the presence and levels of heavy metals and other elements in raw and commercial edible bird nests., Malaysian Journal of Nutrition 2014, 20(3), 377-391.
22. Chen, J. X. J.; Wong, S. F.; Lim, P. K. C.; Mak, J. W., Culture and molecular identification of fungal contaminants in edible bird nests. Food Additives & Contaminants 2015, Part A, 32(12), 2138-2147. [DOI:10.1080/19440049.2015.1101494] [PMID]
23. Karwowska, M.; Kononiuk, A., Nitrates/nitrites in food-Risk for nitrosative stress and benefits. Antioxidants 2020, 9(3), 241. [DOI:10.3390/antiox9030241] [PMID] [PMCID]
24. Ningrum, S. G., Food safety management system in edible bird's nest industry: A review. Journal of Applied Veterinary Science & Technology 2023, 4(1). [DOI:10.20473/javest.V4.I1.2023.41-51]
25. Huda, N.; Shukri, M.; Nawi, N.; Abdullah, A.; Man, N., Consumer's Perception on the quality of controversial contents in edible bird's nest products 2018, 4(1): 1-9.
26. Yeo, B. H.; Tang, T. K.; Wong, S. F.; Tan, C. P.; Wang, Y.; Cheong, L. Z.; Lai, O. M., Potential residual contaminants in edible bird's nest. Frontiers in pharmacology 2021, 12(631136). [DOI:10.3389/fphar.2021.631136] [PMID] [PMCID]
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