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Neuroscience Updates 2024, 2(1): 122-131 |
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Elsattar Ahmed M A, El-Gemaie D S, Ahmed Hussein A H, Soliman Wadan A. The Role of Synaptic Autophagy in Neurodegeneration: Mechanisms and Therapeutic Opportunities. Neuroscience Updates 2024; 2 (1) :122-131
URL: http://neuroupdates.de/article-1-117-en.html
URL: http://neuroupdates.de/article-1-117-en.html
Mohamed Abd Elsattar Ahmed1 
, Dana Saeed El-Gemaie2 , Abdelnaser Hussein Ahmed Hussein3 , Al-Hassan Soliman Wadan *4
, Dana Saeed El-Gemaie2 , Abdelnaser Hussein Ahmed Hussein3 , Al-Hassan Soliman Wadan *4
1- Faculty of Dentistry, Sinai University, Kantara Branch, Ismailia, Egypt
2- Department of Endodontics, Faculty of Dentistry, Galala University, Suez, Egypt
3- Faculty of Dentistry, Sinai University, Arish Branch, North Sinai, Egypt
4- Department of Oral Biology, Faculty of Dentistry, Galala University, Suez, Egypt
2- Department of Endodontics, Faculty of Dentistry, Galala University, Suez, Egypt
3- Faculty of Dentistry, Sinai University, Arish Branch, North Sinai, Egypt
4- Department of Oral Biology, Faculty of Dentistry, Galala University, Suez, Egypt
Abstract: (7222 Views)
This review explores the critical role of synaptic autophagy in neurodegeneration, highlighting its mechanisms and potential therapeutic avenues. Neurons rely on synapses for efficient communication and information processing, with autophagy serving as a vital cellular process for maintaining synaptic integrity under various physiological conditions. The review discusses the different forms of autophagy, macroautophagy, microautophagy, and chaperone-mediated autophagy and their influence on synaptogenesis, synaptic elimination, and overall synaptic transmission. We examine the relationship between impaired autophagic activity and the pathogenesis of neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, which are associated with decreased synaptic function due to disrupted protein turnover and organelle quality control. Furthermore, the involvement of key signalling pathways, including the mTOR pathway, in regulating autophagy and synaptic health is discussed. By elucidating the interplay between autophagy and synaptic dynamics, this review underscores the potential of targeting autophagy-related pathways as a therapeutic strategy in neurodegenerative diseases, offering insights into the mechanisms underlying synaptic dysfunction and the broader implications for neuronal health.
Type of Study: Review Article |
Subject:
Neurodegenerative Disease
Received: 2024/10/28 | Accepted: 2024/12/10 | Published: 2024/12/20
Received: 2024/10/28 | Accepted: 2024/12/10 | Published: 2024/12/20
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