Volume 3, Issue 1 (1-2025)                   Neuroscience Updates 2025, 3(1): 51-61 | Back to browse issues page

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Prakash A J, Kukchishvili M, Alavidze K, Mohamed Khider M A, Afanwi Q C, Yousuf Elnour M M. Regenerative Peripheral Nerve Interfaces for management of Phantom limb pain in amputees. Neuroscience Updates 2025; 3 (1) :51-61
URL: http://neuroupdates.de/article-1-126-en.html
Regenerative Peripheral Nerve Interfaces for management of Phantom limb pain in amputees
Arjun Jay Prakash *1 , Mariam Kukchishvili1 , Ketevani Alavidze2 , Moustapha Abdelgadir Mohamed Khider3 , Quirina Cho Afanwi4 , Mohammed Muneer Yousuf Elnour5
1- Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia
2- David Tvildiani Medical University, Tbilisi, Georgia
3- Tbilisi State Medical University, Tbilisi, Georgia
4- New Vision University, Tbilisi, Georgia
5- Hamad General Hospital, Doha, Qatar
Abstract:   (15 Views)
Phantom limb pain (PLP) and symptomatic neuromas remain major barriers to recovery after limb amputation, often limiting prosthetic use, mobility, and quality of life. Regenerative Peripheral Nerve Interfaces (RPNIs) have emerged as a promising biologically grounded technique for both neuroma prevention and targeted treatment of neuropathic post-amputation pain. This review synthesizes current evidence on RPNIs with specific attention to their surgical design, neurophysiological basis, and clinical effectiveness in reducing PLP and residual limb pain. In addition, the review examines mechanisms of axonal regeneration, the role of denervated muscle grafts in providing physiologic end-targets, and the potential of RPNIs to restore stable, high-fidelity motor signals for myoelectric prosthetic control. Comparative insights with Targeted Muscle Reinnervation (TMR) are included where appropriate. The aim is to provide a consolidated understanding of how RPNIs function at biological, electrophysiological, and clinical levels, and to identify current limitations and future directions in post-amputation nerve reconstruction.
Keywords: Regenerative Peripheral Nerve Interface, Phantom Limb Pain, Phantom Limb Syndrome, Neuropathic Pain, Bionic Prosthesis, Myoelectric Control
     
Type of Study: Review Article | Subject: Clinical Neuroscience
Received: 2025/05/25 | Accepted: 2025/07/20 | Published: 2025/07/30
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